Anatomy
6 questionsWhat type of joint is the 1st carpometacarpal joint?
What anatomical structures are involved in the closure of the fossa ovalis?
The nutrient artery to the femur is?
Which of these best describes the renal angle?
All of the following arteries are branches of the coeliac trunk, EXCEPT which one?
Risorius is a muscle of?
NEET-PG 2012 - Anatomy NEET-PG Practice Questions and MCQs
Question 391: What type of joint is the 1st carpometacarpal joint?
- A. Pivot
- B. Hinge
- C. Ball and Socket
- D. Saddle (Correct Answer)
Explanation: ***Saddle*** - The **1st carpometacarpal joint** (thumb CMC joint) is a classic example of a **saddle joint** due to the reciprocal concave-convex opposing surfaces of the trapezium and the first metacarpal [1]. - This unique shape allows for a wide range of motion, including **flexion/extension**, **abduction/adduction**, and **opposition**, which is crucial for thumb function. *Pivot* - A **pivot joint** allows for rotational movement around a single axis, like the **atlantoaxial joint** (C1-C2) or the **proximal radioulnar joint**. - This type of motion is not characteristic of the 1st carpometacarpal joint. *Hinge* - A **hinge joint** permits movement in only one plane, like the **elbow** or **interphalangeal joints**, allowing for **flexion and extension**. - The 1st carpometacarpal joint has a greater degree of freedom than a hinge joint. *Ball and Socket* - A **ball and socket joint** offers the greatest range of motion, allowing for movement in all planes, including **circumduction and rotation**, such as the **shoulder** and **hip joints**. - While the 1st carpometacarpal joint is highly mobile, it does not achieve the full range of motion of a ball and socket joint.
Question 392: What anatomical structures are involved in the closure of the fossa ovalis?
- A. Septum primum + Endocardial cushion
- B. Septum primum + Septum secundum (Correct Answer)
- C. Endocardial cushions + Septum secundum
- D. None of the options
Explanation: The septum primum acts as a valve, closing against the septum secundum postnatally due to changes in atrial pressure. This fusion effectively closes the foramen ovale, leading to the formation of the fossa ovalis. The endocardial cushions are important for the formation of the atrial and ventricular septa, as well as the AV valves, but not directly for the closure of the fossa ovalis. The septum primum is directly involved, but its apposition with the endocardial cushions doesn't close the foramen ovale. While both structures contribute to heart development, their direct interaction is not responsible for the closure of the fossa ovalis. The septum secundum forms the muscular rim of the fossa ovalis, and the endocardial cushions are critical for atrial septation, but not the final closure here. This option is incorrect because the specific combination of septum primum and septum secundum is indeed responsible for the closure of the fossa ovalis.
Question 393: The nutrient artery to the femur is?
- A. Profunda femoris artery (Correct Answer)
- B. Femoral artery
- C. Popliteal artery
- D. Medial circumflex femoral artery
Explanation: ***Profunda femoris artery*** - The **profunda femoris artery** (deep femoral artery) is the main blood supply to the **femur's diaphysis** via its perforating branches. - Typically, the **second perforating branch** gives rise to the nutrient artery, which enters the bone through the **nutrient foramen** in the middle third of the femoral shaft. *Femoral artery* - The **femoral artery** is the main artery of the thigh and gives off several branches, including the profunda femoris artery. - While it is the source of blood for the entire lower limb, it does not directly give rise to the main **nutrient artery of the femur**. *Popliteal artery* - The **popliteal artery** is a continuation of the femoral artery in the popliteal fossa behind the knee. - It primarily supplies structures around the knee joint and the lower leg, not the direct **diaphyseal nutrient supply** to the femur. *Medial circumflex femoral artery* - The **medial circumflex femoral artery** primarily supplies the head and neck of the femur, crucial for its vascularity, especially in children. - It does not serve as the **main nutrient artery** for the femoral shaft (diaphysis).
Question 394: Which of these best describes the renal angle?
- A. The angle between the latissimus dorsi and the 12th rib
- B. The angle between the erector spinae and the iliac crest
- C. The angle between the 12th rib and the erector spinae (Correct Answer)
- D. The angle between the 12th rib and the rectus abdominis
Explanation: ***The angle between the 12th rib and the erector spinae*** - The **renal angle** (also known as the costovertebral angle) is the space formed by the junction of the **12th rib** and the **erector spinae muscles** laterally. - This anatomical landmark is clinically significant for assessing **kidney pain** or inflammation (e.g., in pyelonephritis) through percussion. *The angle between the latissimus dorsi and the 12th rib* - While the **latissimus dorsi** is a significant back muscle, it is not the primary anatomical landmark that defines the renal angle. - The renal angle specifically refers to the relationship between the rib cage and the deeper spinal muscles. *The angle between the erector spinae and the iliac crest* - This description refers to a region lower down on the back, closer to the **pelvis**, and not directly related to the position of the kidneys. - The **iliac crest** defines the upper border of the pelvis, far from the kidney's typical location relative to the 12th rib. *The angle between the 12th rib and the rectus abdominis* - The **rectus abdominis** muscle is located on the anterior (front) aspect of the abdomen, involved in trunk flexion. - This muscle is anatomically distinct and separate from the posterior flank region where the kidneys are located and where the renal angle is assessed.
Question 395: All of the following arteries are branches of the coeliac trunk, EXCEPT which one?
- A. Splenic artery
- B. Left gastric artery
- C. Common hepatic artery
- D. Right gastric artery (Correct Answer)
Explanation: ***Right gastric artery*** - The **right gastric artery** typically originates from the **proper hepatic artery**, which is a branch of the common hepatic artery. - Therefore, it is not a direct branch of the coeliac trunk itself. *Left gastric artery* - The **left gastric artery** is one of the three main direct branches of the **coeliac trunk**. - It supplies the lesser curvature of the stomach and the abdominal esophagus. *Splenic artery* - The **splenic artery** is another major direct branch of the **coeliac trunk**. - It supplies the spleen, pancreas, and parts of the stomach via various branches. *Common hepatic artery* - The **common hepatic artery** is the third main direct branch of the **coeliac trunk**. - It gives rise to the proper hepatic artery and the gastroduodenal artery, supplying the liver, gallbladder, pylorus, and duodenum.
Question 396: Risorius is a muscle of?
- A. Mastication
- B. Deglutition
- C. Facial expression (Correct Answer)
- D. Eye movement
Explanation: Facial expression - The **risorius muscle** retracts the **corner of the mouth** laterally, contributing to smiling or grimacing. - It falls under the category of **mimetic muscles**, all of which are innervated by the **facial nerve (cranial nerve VII)**. *Mastication* - Muscles of mastication, such as the **masseter**, **temporalis**, and **pterygoids**, are primarily involved in **chewing** and moving the mandible. - These muscles are innervated by the **trigeminal nerve (cranial nerve V)**, not the facial nerve. *Deglutition* - Deglutition refers to the process of **swallowing**, involving muscles of the **pharynx** and **larynx**. - Examples include the **palatoglossus**, **stylopharyngeus**, and **superior pharyngeal constrictor**. *Eye movement* - Muscles responsible for eye movement are the **extrinsic ocular muscles**, such as the **recti** and **oblique muscles** [1]. - These muscles are innervated by the **oculomotor (III)**, **trochlear (IV)**, and **abducens (VI)** cranial nerves. *Note: No provided references mention the risorius muscle, mimetic muscles, or muscles of mastication; citations are applied only to supported sub-topics.*
Pharmacology
1 questionsWhich of the following is a guanosine analogue?
NEET-PG 2012 - Pharmacology NEET-PG Practice Questions and MCQs
Question 391: Which of the following is a guanosine analogue?
- A. Abacavir (Correct Answer)
- B. Bromodeoxyuridine
- C. Allopurinol
- D. Acyclovir
Explanation: ***Abacavir*** - **Abacavir** is a nucleoside reverse transcriptase inhibitor (NRTI) used in HIV treatment. - It is a **carbocyclic analogue of guanosine** (specifically, a 2'-deoxyguanosine analogue). - Structurally, it contains a modified cyclopentane ring instead of the ribose sugar, but retains the guanine base, making it a guanosine analogue. *Acyclovir* - **Acyclovir** is also a **guanosine analogue** - specifically an acyclic guanosine analogue. - It is an antiviral drug used to treat herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. - Note: Both Abacavir and Acyclovir are technically guanosine analogues; in this PYQ context, Abacavir is the expected answer. *Bromodeoxyuridine* - **Bromodeoxyuridine** is a **pyrimidine analogue**, specifically a thymidine analogue. - It is incorporated into DNA during replication and is used in research and as a radiosensitizer. *Allopurinol* - **Allopurinol** is a purine analogue (hypoxanthine analogue) that inhibits xanthine oxidase. - It is primarily used to treat **gout** and prevent kidney stones by reducing uric acid production. - While it's a purine derivative, it is not specifically a guanosine analogue.
Physiology
3 questionsWhat is the consequence of tibial nerve injury/palsy?
Which of the following statements regarding the lower esophageal sphincter is TRUE?
Gastric secretions are essential for absorption of -
NEET-PG 2012 - Physiology NEET-PG Practice Questions and MCQs
Question 391: What is the consequence of tibial nerve injury/palsy?
- A. Loss of plantar flexion (Correct Answer)
- B. Dorsiflexion of foot at ankle joint
- C. Loss of sensation of dorsum of foot
- D. Paralysis of muscles of anterior compartment of leg
Explanation: **Loss of plantar flexion** - The **tibial nerve** innervates the muscles of the **posterior compartment of the leg**, which are primarily responsible for **plantar flexion** of the foot. - Injury to this nerve directly impairs the function of muscles like the gastrocnemius, soleus, and tibialis posterior, leading to a significant loss of the ability to point the foot downwards. *Dorsiflexion of foot at ankle joint* - **Dorsiflexion** is primarily mediated by muscles in the **anterior compartment of the leg**, such as the tibialis anterior, which are innervated by the **deep fibular nerve**. - Tibial nerve injury would not directly affect these muscles or their function; rather, it leads to issues with the opposing action. *Loss of sensation of dorsum of foot* - Sensation to the **dorsum of the foot** is primarily supplied by the **superficial fibular nerve** (for most of the dorsum) and the **deep fibular nerve** (for the first web space). - While the tibial nerve provides sensation to the sole of the foot, it does not typically innervate the dorsum. *Paralysis of muscles of anterior compartment of leg* - The muscles of the **anterior compartment of the leg** (e.g., tibialis anterior, extensor digitorum longus, extensor hallucis longus) are innervated by the **deep fibular nerve**. - A tibial nerve injury would paralyze muscles in the posterior compartment, not the anterior compartment.
Question 392: Which of the following statements regarding the lower esophageal sphincter is TRUE?
- A. It relaxes in response to swallowing. (Correct Answer)
- B. It remains contracted during swallowing to prevent regurgitation.
- C. Its tone is primarily influenced by the myogenic properties of the smooth muscle.
- D. It contracts in response to gastric distension.
Explanation: ***It relaxes in response to swallowing.*** - The **lower esophageal sphincter (LES)** normally maintains high resting tone to prevent gastroesophageal reflux but **relaxes completely during swallowing** to allow passage of food into the stomach. - This relaxation (called **receptive relaxation**) is mediated by **vagal nerve stimulation** through release of nitric oxide (NO) and vasoactive intestinal peptide (VIP). - The relaxation occurs **before the peristaltic wave arrives**, allowing coordinated transit of the bolus. *It remains contracted during swallowing to prevent regurgitation.* - This is **incorrect** - the LES must **relax during swallowing** to allow food passage into the stomach. - Failure of LES relaxation during swallowing is the pathophysiology of **achalasia**, leading to dysphagia. - The LES only maintains contraction between swallows to prevent reflux. *Its tone is primarily influenced by the myogenic properties of the smooth muscle.* - While the LES contains smooth muscle with intrinsic myogenic properties, its tone is **predominantly regulated by neural and hormonal factors**. - **Neural control:** Vagal cholinergic pathways (increase tone), non-adrenergic non-cholinergic (NANC) pathways with NO and VIP (decrease tone). - **Hormonal factors:** Gastrin increases tone, while progesterone, CCK, and secretin decrease tone. *It contracts in response to gastric distension.* - This is **incorrect** - gastric distension actually triggers **transient LES relaxations (TLESRs)**, which are the primary mechanism of physiological reflux. - TLESRs are vagally mediated reflex responses that allow venting of gastric air. - Increased LES contraction in response to gastric distension would be counterproductive.
Question 393: Gastric secretions are essential for absorption of -
- A. Cobalamin (Correct Answer)
- B. Fat
- C. Thiamine
- D. Folic acid
Explanation: ***Cobalamin*** - **Intrinsic factor**, secreted by gastric parietal cells, is crucial for the absorption of **vitamin B12 (cobalamin)** in the terminal ileum [1]. - Without sufficient intrinsic factor, **pernicious anemia** can develop due to impaired B12 absorption [2]. *Fat* - Fat digestion primarily occurs in the **small intestine** with the help of **bile salts** and **pancreatic lipases**. - While gastric lipase begins some fat digestion, it's not essential for overall fat absorption. *Thiamine* - **Thiamine (vitamin B1)** is absorbed in the jejunum and ileum, primarily via **active transport** and passive diffusion. - Gastric secretions do not play a direct, essential role in its absorption. *Folic acid* - **Folic acid** is absorbed in the **duodenum and jejunum** as monoglutamates after being deconjugated from polyglutamate forms. - This process is not directly dependent on gastric secretions [2].