FMGE 2025 Practice Questions

Q: A female presents with multiple small, pink, umbilicated papules on the face. What is the most likely diagnosis?

Molluscum contagiosum. ***Molluscum contagiosum*** - This condition, caused by a **poxvirus**, classically presents as multiple, discrete, small (2-5 mm), dome-shaped, pink or skin-colored papules with central **umbilication**. - It is a common, benign skin infection that spreads through direct contact or fomites and is frequently seen in children, sexually active adults, and immunocompromised individuals. *Herpes simplex* - Herpes simplex virus infection typically manifests as clusters of painful **vesicles** (small blisters) on an erythematous base, which later ulcerate and crust over. - The primary lesions are not solid papules and lack the characteristic central umbilication seen in molluscum. *HPV* - Human Papillomavirus (HPV) causes warts (verrucae), which are typically rough, hyperkeratotic papules (**verruca vulgaris**) or flat-topped papules (**verruca plana**). - Warts do not characteristically present with the smooth surface and central depression seen in molluscum contagiosum. *Acne vulgaris* - Acne is a disorder of the pilosebaceous unit, presenting with a variety of lesions including **comedones** (blackheads and whiteheads), inflammatory papules, and pustules. - Acne lesions are not umbilicated and are often associated with follicular inflammation and sebum production.

Q: Which of the following best describes the characteristic lesion of Kaposi sarcoma?

A raised, purple-red lesion. ***A raised, purple-red lesion*** - Kaposi sarcoma is a vascular tumor caused by **Human Herpesvirus-8 (HHV-8)**, presenting as violaceous (purple-red) macules, papules, or nodules on the skin and mucosa. - These lesions are common in immunocompromised individuals, particularly those with **HIV/AIDS**, and are characterized by the proliferation of endothelial cells. *A yellow lesion containing pus* - This description is characteristic of a **pustule** or an **abscess**, which are typically signs of a bacterial infection, such as those caused by **Staphylococcus aureus**. - Kaposi sarcoma is a neoplastic lesion, not an acute purulent infection, and does not contain pus. *A white, striated lesion that cannot be scraped off* - This is the classic presentation of **oral hairy leukoplakia**, a benign mucosal lesion caused by the **Epstein-Barr virus (EBV)**, also seen in immunocompromised patients. - It differs from Kaposi sarcoma in its color (white vs. purple-red), location (typically lateral tongue), and causative virus. *Small, red erosions* - This description is more consistent with conditions like **herpes simplex virus (HSV)** infection, where vesicles rupture to form erosions, or with erosive inflammatory dermatoses. - Kaposi sarcoma typically manifests as proliferative papules or nodules, not as primary erosions.

Q: A patient with borderline tuberculoid leprosy presents with the following findings. Which type of hypersensitivity reaction and nerve is enlarged?

Type 4 & greater auricular nerve. ***Type 4 & greater auricular nerve*** - Borderline tuberculoid leprosy is characterized by a strong **cell-mediated immune response** against *Mycobacterium leprae*, which manifests as a **Type 4 (delayed-type) hypersensitivity** reaction leading to granuloma formation. - The image shows a thickened, cord-like structure in the neck, which is characteristic of an enlarged **greater auricular nerve**, the most commonly involved cutaneous nerve of the head and neck in leprosy. *Type 1 & greater auricular nerve* - **Type 1 hypersensitivity** is an immediate, **IgE-mediated** reaction (e.g., anaphylaxis) and is not the immunological basis for nerve damage or skin lesions in tuberculoid leprosy. - The pathogenesis of tuberculoid leprosy involves a **delayed-type** T-cell response, which takes days to develop, unlike the rapid onset of Type 1 reactions. *Type 2 & greater auricular nerve* - **Type 2 hypersensitivity** is an **antibody-dependent cytotoxic** reaction, which is not the primary mechanism in tuberculoid leprosy's pathology. - While immune reactions occur in leprosy, Type 2 is not the correct classification for the T-cell-mediated granulomatous inflammation seen in the tuberculoid form. *Type 3 & anterior auricular nerve* - **Type 3 hypersensitivity** involves **immune-complex deposition** and is characteristic of **Erythema Nodosum Leprosum (ENL)**, a complication typically seen in lepromatous leprosy, not borderline tuberculoid. - The enlarged nerve shown is clearly the **greater auricular nerve** due to its location crossing the sternocleidomastoid muscle; the **anterior auricular nerve** is located more anteriorly and is not typically affected this prominently.

Q: A patient presents with a history of dilation & curettage (D&C). Subsequent diagnostic tests reveal all hormone levels, including progesterone and estrogen, to be within the normal range. Based on this clinical presentation, which of the following is the most likely diagnosis?

Asherman Syndrome. ***Asherman Syndrome***- This diagnosis is characterized by the presence of **intrauterine adhesions** (synechiae), typically caused by injury to the **basal layer of the endometrium** following procedures like **D&C**.- The normal **estrogen** and **progesterone** levels indicate normal ovarian function, suggesting the pathology is uterine (end-organ failure to respond to hormones/obstruction) rather than central or ovarian.*Polycystic Ovary Syndrome (PCOS)*- PCOS is associated with chronic **anovulation** and features of **hyperandrogenism** (hirsutism, acne) but usually presents with oligomenorrhea rather than complete amenorrhea following D&C.- Hormonal analysis typically shows an elevated **LH/FSH ratio** and potentially high androgens, resulting in *abnormal* cyclical hormone patterns, unlike the normal levels noted here.*Premature Ovarian Insufficiency (POI)*- POI is characterized by the cessation of ovarian function before age 40, leading to a state of **hypoestrogenism** and low progesterone.- Lab tests would reveal *markedly elevated* **FSH** and *low* **estrogen** due to loss of negative feedback, directly contradicting the finding of normal hormone levels in this patient.*Endometriosis*- Endometriosis involves ectopic endometrial tissue and typically presents with symptoms like **severe dysmenorrhea**, **dyspareunia**, and chronic pelvic pain.- While severe cases can impact fertility, it does not typically cause complete secondary amenorrhea with *normal* cyclical estrogen and progesterone levels; this clinical picture points overwhelmingly to a mechanical uterine issue.

Q: The following light reflex is seen in a patient. How much is the deviation?

45 PD. ***45 PD*** - The image displays the **Hirschberg test** (corneal light reflex test), which estimates the angle of strabismus. The light reflex is displaced nasally in the left eye, indicating an outward deviation (**exotropia**). - A reflex located approximately midway between the pupil margin and the limbus corresponds to a deviation of about 22.5 degrees, which is equivalent to **45 prism diopters (PD)**. *30 PD* - A deviation of 30 PD corresponds to approximately 15 degrees, where the light reflex would be seen at the **pupillary margin**. - This represents a smaller deviation than what is depicted in the image. *90 PD* - This value corresponds to a large deviation of 45 degrees, where the light reflex would be located at the **limbus** (the junction of the cornea and sclera). - The light reflex in the image is positioned midway between the pupil and limbus, indicating a smaller deviation than what would be seen with a full 90 PD deviation. *90°* - This is an extremely large deviation and is also an incorrect unit of measurement for this test; **prism diopters (PD)** are the standard unit used to quantify strabismus. - One degree of deviation is roughly equal to two prism diopters, making a 90-degree deviation (180 PD) anatomically inconsistent with the image.

Q: A patient presents with a down and out right eye with ptosis since birth. What is the nerve palsy?

3rd nerve palsy. ***3rd nerve palsy (Correct Answer)*** - The **oculomotor nerve (CN III)** supplies the levator palpebrae superioris, leading to **ptosis**, and most extraocular muscles (superior rectus, medial rectus, inferior rectus, and inferior oblique) - When CN III is paralyzed, the unopposed actions of **CN IV (superior oblique)** and **CN VI (lateral rectus)** pull the eye into the characteristic **"down and out"** position - **Congenital 3rd nerve palsy** presents with ptosis and the down-and-out eye position from birth - This is the classic triad: **ptosis + down and out eye + dilated pupil** (if pupil-involving) *4th nerve palsy (Incorrect)* - Palsy of the **trochlear nerve (CN IV)** affects only the superior oblique muscle - Presents with impaired **downward and inward movement** and **intorsion** - Typically causes **vertical diplopia** (especially on downward gaze) and compensatory **head tilt** to the opposite side - Does **NOT** cause ptosis or the pronounced "down and out" position *6th nerve palsy (Incorrect)* - Palsy of the **abducens nerve (CN VI)** affects only the lateral rectus muscle - Causes failure of **abduction** (outward movement), resulting in the eye being pulled **inward** (esotropia) - Does **NOT** cause ptosis or downward deviation of the eye *7th nerve palsy (Incorrect)* - The **facial nerve (CN VII)** controls facial muscles, including orbicularis oculi - Causes **lagophthalmos** (inability to close the eyelid) and facial weakness, NOT ptosis - Does **NOT** affect extraocular movements or eye position

Q: A posterior staphyloma was observed on indirect ophthalmoscopy. What is the likely diagnosis?

High myopia. ***High myopia*** - A **posterior staphyloma** is an outpouching of the sclera at the posterior pole of the eye, which is a pathognomonic sign of **pathological** or **high myopia** due to excessive axial elongation. - Other associated fundus findings in high myopia include **chorioretinal atrophy**, **lacquer cracks** (breaks in Bruch's membrane), and an increased risk of **retinal detachment**. *Hypermetropia* - Hypermetropia (farsightedness) is characterized by a **shorter axial length**, which is the opposite of the anatomical changes seen in high myopia that lead to staphyloma formation. - Fundus examination in hypermetropia may reveal a small, crowded optic disc, sometimes referred to as **pseudopapilledema**, but not scleral ectasia. *Primary open-angle glaucoma* - The primary funduscopic sign of glaucoma is progressive damage to the **optic nerve head**, manifesting as an increased **cup-to-disc ratio** and thinning of the neuroretinal rim. - While a myopic optic disc can be difficult to assess for glaucoma, a staphyloma itself is a feature of the sclera and retina, not a primary sign of glaucoma. *Retinitis pigmentosa* - This is an inherited retinal dystrophy with characteristic fundus findings including **bone-spicule pigmentation** in the mid-periphery, **arteriolar attenuation**, and **waxy pallor of the optic disc**. - These changes result from photoreceptor and retinal pigment epithelium degeneration, and are not associated with the formation of a posterior staphyloma.

Q: A child accidentally took a bottle full of iron tablets. Which of the drugs is used as an antidote for iron poisoning?

Deferoxamine. ***Deferoxamine***- It is the standard **chelating agent** administered via intravenous or intramuscular routes for treating life-threatening acute **iron overdose** (toxicity) [1].- It binds strongly to free **ferric iron (Fe3+)** in the circulation, forming the non-toxic, water-soluble complex *ferrioxamine* which is then excreted in the urine [1].*Luspatercept*- This is an **erythroid maturation agent** used to treat **anemia** associated with *myelodysplastic syndromes* (MDS) and *beta-thalassemia*.- It functions by modulating the **TGF-β signaling pathway** to reduce ineffective erythropoiesis, not by direct heavy metal chelation.*Deferiprone*- This is an **oral iron chelator** primarily used for the management of **chronic iron overload**, often seen in patients receiving frequent blood transfusions (e.g., thalassemia).- While it removes iron, it is generally less effective and not the first-line choice for the management of acute life-threatening pediatric poisoning, where **intravenous Deferoxamine** is mandatory.*DMSA*- DMSA (Succimer) is a heavy metal chelating agent primarily indicated for poisoning by **lead**, **arsenic**, and **mercury**.- It is administered orally and is structurally distinct from iron chelators like deferoxamine, making it unsuitable for treating acute iron toxicity.

Q: A patient with schizophrenia, developed muscular dystonia and was treated for it. The patient now presents with complaints of dry mouth, dizziness, and hypotension. What is the most likely drug causing these side effects?

Benzotropine. ***Benzotropine***- This drug is an **anticholinergic agent** administered specifically to treat **extrapyramidal symptoms (EPS)** like acute muscular dystonia caused by antipsychotics.- **Dry mouth** is a characteristic manifestation of its peripheral **anticholinergic side effects**, while **dizziness and hypotension** can occur due to central effects or potentiation of adrenergic blockade, particularly when co-administered with antipsychotics.*Risperidone*- Although Risperidone (an atypical antipsychotic) commonly causes EPS and strong **orthostatic hypotension** due to **alpha-1 adrenergic blockade** (dizziness/hypotension), it has moderate anticholinergic activity, making it less likely to be the sole cause of prominent dry mouth.- The patient's presentation suggests a new medication was introduced *after* the dystonia developed; Risperidone was likely the cause of the *initial* dystonia.*Haloperidol*- Haloperidol, a high-potency typical antipsychotic, is a common cause of **muscular dystonia** (EPS).- It has relatively **low anticholinergic activity** and is therefore an improbable cause of severe **dry mouth** compared to agents like Benzotropine.*Propranolol*- Propranolol is a **beta-blocker** typically used to treat antipsychotic-induced **akathisia** or tremor, not acute dystonia.- Its most prominent side effects are related to beta-blockade, such as **bradycardia** and fatigue; it is not routinely associated with significant **dry mouth**.

Q: According to DSM-5 classification, what is the diagnosis for a child who exhibits below-average mathematical skills despite having a normal IQ and age-appropriate learning abilities in other areas, and remains unaffected by a year-long private mathematics tutoring?

Specific learning disorder. ***Specific learning disorder***- The presentation meets the criteria for **Specific Learning Disorder (SLD)**, characterized by persistent difficulties in learning core academic skills (in this case, mathematics) that are significantly below expected levels, despite having **average intellectual functioning (normal IQ)**.- The failure to show improvement despite targeted intervention (private tutoring for a year) confirms the persistence and severity of the **neurodevelopmental basis** of the learning difficulty, which is central to the diagnosis of SLD.*ADHD*- **Attention-Deficit/Hyperactivity Disorder (ADHD)** primarily involves persistent patterns of inattention and/or hyperactivity-impulsivity that interfere with functioning or development.- While ADHD can impair academic performance, the primary deficit described here is specific to **mathematical calculation and reasoning**, rather than generalized difficulties arising from attention regulation issues. *Mathematics learning disorder*- This term refers to the specific impairment outlined (often called **Dyscalculia**), but in the DSM-5, it is classified as a **specifier** under the broader diagnosis of Specific Learning Disorder (SLD), specifically "Specific Learning Disorder, With Impairment in Mathematics."- Since **Specific learning disorder** is provided as an option, it is the formal and overarching diagnostic category that applies in this clinical setting.*Aspergers syndrome*- **Asperger's Syndrome** is an outdated term now grouped under **Autism Spectrum Disorder (ASD)**, which is fundamentally characterized by deficits in social communication and interaction, and restricted, repetitive patterns of behavior.- While individuals with ASD may have uneven skill profiles, the history focuses exclusively on a **specific, isolated academic impairment** in mathematics, without mentioning the core criteria of social deficits.

Question 1

A female presents with multiple small, pink, umbilicated papules on the face. What is the most likely diagnosis?

Accepted Answer

Molluscum contagiosum

Answer

Acne vulgaris

Answer

HPV

Answer

Herpes simplex

Question 2

Which of the following best describes the characteristic lesion of Kaposi sarcoma?

Accepted Answer

A raised, purple-red lesion

Answer

Small, red erosions

Answer

A white, striated lesion that cannot be scraped off

Answer

A yellow lesion containing pus

Question 3

A patient with borderline tuberculoid leprosy presents with the following findings. Which type of hypersensitivity reaction and nerve is enlarged?

Accepted Answer

Type 4 & greater auricular nerve

Answer

Type 1 & greater auricular nerve

Answer

Type 3 & anterior auricular nerve

Answer

Type 2 & greater auricular nerve

Question 4

A patient presents with a history of dilation & curettage (D&C). Subsequent diagnostic tests reveal all hormone levels, including progesterone and estrogen, to be within the normal range. Based on this clinical presentation, which of the following is the most likely diagnosis?

Accepted Answer

Asherman Syndrome

Answer

Endometriosis

Answer

Premature Ovarian Insufficiency (POI)

Answer

Polycystic Ovary Syndrome (PCOS)

Question 5

The following light reflex is seen in a patient. How much is the deviation?

Accepted Answer

45 PD

Answer

90 PD

Answer

30 PD

Answer

90°

Question 6

A patient presents with a down and out right eye with ptosis since birth. What is the nerve palsy?

Accepted Answer

3rd nerve palsy

Answer

4th nerve palsy

Answer

6th nerve palsy

Answer

7th nerve palsy

Question 7

A posterior staphyloma was observed on indirect ophthalmoscopy. What is the likely diagnosis?

Accepted Answer

High myopia

Answer

Retinitis pigmentosa

Answer

Primary open-angle glaucoma

Answer

Hypermetropia

Question 8

A child accidentally took a bottle full of iron tablets. Which of the drugs is used as an antidote for iron poisoning?

Accepted Answer

Deferoxamine

Answer

DMSA

Answer

Deferiprone

Answer

Luspatercept

Question 9

A patient with schizophrenia, developed muscular dystonia and was treated for it. The patient now presents with complaints of dry mouth, dizziness, and hypotension. What is the most likely drug causing these side effects?

Accepted Answer

Benzotropine

Answer

Propranolol

Answer

Risperidone

Answer

Haloperidol

Question 10

According to DSM-5 classification, what is the diagnosis for a child who exhibits below-average mathematical skills despite having a normal IQ and age-appropriate learning abilities in other areas, and remains unaffected by a year-long private mathematics tutoring?

Accepted Answer

Specific learning disorder

Answer

Mathematics learning disorder

Answer

Aspergers syndrome

Answer

ADHD

FMGE 2025

Dermatology

Obstetrics and Gynecology

Ophthalmology

Pharmacology

Psychiatry