Question 1

Q: When 2,3-bisphosphoglycerate (2,3-BPG) levels increase in the blood, how would this affect the oxygen-hemoglobin dissociation curve?

Shift to the right. ***Shift to the right*** - An increase in **2,3-BPG** levels causes a **rightward shift** of the oxygen-hemoglobin dissociation curve, indicating a **decreased affinity of hemoglobin for oxygen**. - This shift facilitates the **release of oxygen to tissues**, which is crucial in conditions like **hypoxia** or **anemia**. *Shift to the left* - A leftward shift would imply an **increased affinity of hemoglobin for oxygen**, hindering oxygen release to tissues. - This typically occurs with **decreased 2,3-BPG**, **alkalosis**, **hypothermia**, or presence of **fetal hemoglobin**. *No change* - **2,3-BPG** is a significant allosteric effector of hemoglobin, and its concentration directly impacts oxygen binding. - Therefore, a change in its levels *will* alter the curve, making "no change" an incorrect option. *Decrease in the oxygen carrying capacity* - A rightward shift of the curve affects hemoglobin's *affinity* for oxygen, not its **total oxygen-carrying capacity**. - Oxygen-carrying capacity is primarily determined by the **hemoglobin concentration** in the blood.

Question

When 2,3-bisphosphoglycerate (2,3-BPG) levels increase in the blood, how would this affect the oxygen-hemoglobin dissociation curve?

Accepted Answer

Shift to the right

Answer

Shift to the left

Answer

No change

Answer

Decrease in the oxygen carrying capacity

Respiratory System — MCQs

Respiratory System — MCQs

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