Immunological Memory and Tolerance Practice Questions

Question 1

Which of the following statements about the secondary immune response is false?

Accepted Answer

Immune response against a subsequent antigenic challenge is absent.

Answer

The lag period is absent or significantly shorter.

Answer

There is a negative phase in the response.

Answer

Only T-dependent antigens are recognized.

Question 2

Which of the following is a specific feature of acquired immunity?

Accepted Answer

Immunological memory

Answer

Affected by genetic makeup

Answer

No antigen exposure

Answer

Immediate response

Question 3

Cell surface molecules involved in peripheral tolerance induction are

Accepted Answer

B7 and CD28

Answer

CD40 and CD40L

Answer

CD34 and CD51

Answer

B7 and CD3

Question 4

All are true regarding the development of T-cells, except?

Accepted Answer

T-cells are located in mantle layer of spleen

Answer

T-cells are formed in bone marrow

Answer

In lymph nodes, T-cells are found in paracortical area

Answer

Maturation of T-cells take place in thymus

Question 5

Which of the following statements regarding rejection of solid organ transplants is true?

Accepted Answer

Hyperacute rejection begins in the operating room with reperfusion of the transplanted organ

Answer

Most immunosuppressive medications are used to prevent chronic rejection

Answer

The major cause of graft failure is acute rejection

Answer

Liver transplants are especially susceptible to hyperacute rejection

Question 6

All of the following are functions of the spleen EXCEPT?

Accepted Answer

Initiation of adaptive immune response from filtration of lymph.

Answer

Clearance of damaged or aged red blood cells (RBCs) from the blood.

Answer

Extramedullary site for hematopoiesis and recycling iron.

Answer

Clearance of encapsulated bacteria from the bloodstream.

Question 7

In fetal life, in which of the following sites are red blood cells NOT produced?

Accepted Answer

Lymph node

Answer

Liver

Answer

Spleen

Answer

Bone marrow

Question 8

What is the first cell in the development of red blood cells?

Accepted Answer

Proerythroblast

Answer

Intermediate normoblast

Answer

Reticulocyte

Answer

Basophilic erythroblast

Question 9

Which of the following does NOT occur during hemostasis?

Accepted Answer

None of the above

Answer

Vasospasm of the blood vessel

Answer

Platelet plug formation

Answer

Dissolution of the clot by plasmin

Question 10

What is the primary site of red blood cell formation in a healthy 20-year-old male?

Accepted Answer

Flat bones

Answer

Long bones

Answer

Liver

Answer

Yolk sac

Immunological Memory and Tolerance — MCQs

Immunological Memory and Tolerance — MCQs

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