Neurology Practice Questions

Q: The common type of cerebral palsy seen in hospitals is –

Spastic. ***Spastic*** - **Spastic cerebral palsy** is the most prevalent form, accounting for approximately 80% of all cases. - It is characterized by **increased muscle tone** (spasticity), leading to stiff and awkward movements. *Diplegia* - **Spastic diplegia** is a subtype of spastic cerebral palsy where primarily the legs are affected, with arm involvement being less severe or absent. - While common, it is a specific distribution pattern within the broader category of spastic cerebral palsy, rather than the overarching common type itself. *Quadriplegia* - **Spastic quadriplegia** is a severe form of spastic cerebral palsy affecting all four limbs, the trunk, and often the face. - It is a significant disability but represents a less common and more debilitating subtype compared to spastic cerebral palsy in general. *Monoplegia* - **Monoplegia** is a very rare form of cerebral palsy where only one limb is affected. - It is one of the least common types of cerebral palsy presentations.

Q: Which of the following electrolyte abnormalities is a cause of status epilepticus in a child?

Hyponatremia. ***Hyponatremia*** - **Hyponatremia** (low sodium levels) can lead to **cerebral edema**, increasing intracranial pressure and predisposing to seizures, including status epilepticus, especially in children. - Rapid shifts in fluid balance and electrolyte disturbances, such as those seen with severe hyponatremia, can destabilize neuronal membranes and trigger **sustained seizure activity**. *Hypokalemia* - While significant **hypokalemia** (low potassium) affects cardiac and muscular function, it is **less commonly a direct cause of seizures** or status epilepticus compared to sodium imbalances. - Severe hypokalemia can impact neuronal excitability but primarily causes **muscle weakness** and **cardiac arrhythmias**. *Hyperkalemia* - **Hyperkalemia** (high potassium) primarily affects **cardiac conduction** and neuromuscular function, leading to **bradycardia** or **cardiac arrest**. - It is **not typically associated with seizures** or status epilepticus in children. *Hypernatremia* - **Hypernatremia** (high sodium) indicates a relative water deficit, leading to cell shrinkage and potentially **intracranial hemorrhage** or **thrombosis**. - While severe hypernatremia can cause neurological symptoms like **lethargy** or **coma**, it is **less commonly a direct cause of status epilepticus** compared to hyponatremia.

Q: What is the drug of choice for acute treatment of febrile seizures?

Diazepam. ***Diazepam*** - **Diazepam** is the drug of choice for the acute treatment of febrile seizures because of its **rapid onset of action** and effectiveness in stopping ongoing seizures [1]. - It is often administered **rectally** or intramuscularly in an emergency setting by parents or caregivers, which is crucial given the urgency of treating a seizure [1]. *Phenobarbitone* - While **phenobarbitone** has anticonvulsant properties, it is typically used for **long-term prophylaxis** in children with recurrent or high-risk febrile seizures, not for acute treatment. - It has a **slower onset of action** and can cause **sedation**, making it less suitable for immediate seizure termination [3]. *Valproate* - **Valproate** is an antiepileptic drug used for various seizure types but is generally **not recommended for acute treatment of febrile seizures** due to its slower onset and potential side effects in young children [2]. - Its use is more relevant in epilepsy management and **long-term seizure prevention**, not as a first-line agent for acute febrile seizure termination [2]. *Carbamazepine* - **Carbamazepine** is primarily used for **focal seizures** and **trigeminal neuralgia** and is not indicated for the acute management of febrile seizures [2]. - It has a **slower onset** and a different mechanism of action that is not optimal for rapidly stopping a febrile seizure.

Q: A 15-year-old boy presented with day dreaming and decline in school performance. The likely possibility is?

Typical absence seizure. ***Typical absence seizure*** - This presentation of **daydreaming** and **decline in school performance** is characteristic of typical absence seizures, which involve brief episodes of impaired consciousness without loss of postural tone. - These seizures are common in childhood and adolescence, often manifesting as staring spells that can be mistaken for inattention. *Atonic seizure* - An atonic seizure involves a **sudden loss of muscle tone**, leading to a sudden drop or fall, which is not described here. - While it can cause brief loss of consciousness, the primary feature is the motor event. *Myoclonic seizure* - Myoclonic seizures are characterized by **sudden, brief, jerking movements** of a muscle or muscle group. - They are typically very brief and do not involve the sustained staring spell or impaired awareness described. *Atypical absence seizure* - Atypical absence seizures have a **more gradual onset and offset** than typical absence seizures, and may be associated with more noticeable motor signs and less complete loss of awareness. - Daydreaming and decline in school performance are classic for typical, not atypical, absence seizures.

Q: Febrile seizure is called as 'complex' when it lasts for?

> 15 minutes. ***> 15 minutes*** - A **complex febrile seizure** is defined by one or more of the following characteristics: duration longer than **15 minutes**, occurrence more than once within 24 hours, or a focal nature. - This longer duration distinguishes it from a **simple febrile seizure**, which typically lasts less than 15 minutes. *> 30 minutes* - While a seizure lasting more than **30 minutes** is certainly complex, the clinical threshold for defining a complex febrile seizure is met at **15 minutes**. - A seizure lasting over 30 minutes would also be classified as **status epilepticus**, which is a more severe condition requiring urgent intervention. *> 5 minutes* - A seizure lasting more than **5 minutes** but less than 15 minutes is usually still considered a **simple febrile seizure** if other complex features are absent. - Febrile seizures often last between 2 to 5 minutes, making this duration not typically indicative of complexity on its own. *> 10 minutes* - A seizure lasting more than **10 minutes** is approaching the complex definition but does not quite meet the standard **15-minute threshold** for a complex febrile seizure based on duration. - It is still commonly considered within the range of a simple febrile seizure unless other factors like *focality* or recurrence are present.

Q: A pediatric patient with progressively developing degenerative neurologic disease/disorder has an elevated CSF antibody titer to measles virus. You should suspect which of the following?

Possible subacute sclerosing panencephalitis (SSPE). ***Possible subacute sclerosing panencephalitis (SSPE)*** - **SSPE** is a rare, fatal, progressive neurodegenerative disease caused by **persistent measles virus infection** of the central nervous system. - The diagnosis is strongly supported by **markedly elevated CSF antibody titer to measles virus** (often >1:256) with increased CSF measles IgG. - Clinical features include progressive intellectual deterioration, behavioral changes, myoclonic jerks, and eventual vegetative state. - Typically occurs **7-10 years after initial measles infection**, with peak incidence in children and adolescents. - EEG shows characteristic **periodic complexes (Radermecker complexes)** with burst-suppression pattern. *Acute Lyme disease* - Caused by the bacterium *Borrelia burgdorferi*, transmitted by tick bites. - Neurological manifestations (neuroborreliosis) include facial palsy, meningitis, and radiculopathy—not progressive degenerative disease. - Diagnosis involves **Lyme serology** (ELISA, Western blot), not measles antibodies. - Presents with classic **erythema migrans rash** in early stage. *Fifth disease* - Caused by **Parvovirus B19** and typically manifests as "slapped cheek" rash (erythema infectiosum). - A self-limited illness in immunocompetent children with no association with progressive neurodegeneration. - Not associated with **elevated measles antibody titers** or chronic CNS infection. *Possible hepatitis B infection* - Caused by **hepatitis B virus** and primarily affects the liver, causing acute or chronic hepatitis. - Does not cause **progressive degenerative neurological disease** or elevated measles virus antibodies. - Neurological complications are rare and typically related to vasculitis, not direct CNS infection.

Q: Which of the following statements concerning spina bifida is True?

Spina bifida occulta occurs most often at L5-S1 level. **Spina bifida occulta occurs most often at L5-S1 level** - **Spina bifida occulta** is the mildest form of spina bifida, characterized by an incomplete closure of the vertebral arch without protrusion of the spinal cord or meninges. - The most common location for spina bifida occulta is the **L5-S1 vertebral level**, which often presents as a skin dimple, tuft of hair, or discolored patch in the lumbar region. *Chromosomal abnormalities can be identified in approximately 50% of patients* - **Chromosomal abnormalities** are found in a minority of patients with spina bifida, typically less than 10%, when evaluating for genetic causes. - While single-gene mutations or environmental factors contribute, spina bifida is most often considered a **multifactorial condition** rather than solely chromosomal. *A myelomeningocele is the most common type of spina bifida* - A **myelomeningocele** is the most severe and a common type of spina bifida where the spinal cord and meninges protrude through an opening in the spine. - However, **spina bifida occulta** is statistically the most common type overall, though it is often asymptomatic and may go undiagnosed. *Additional congenital abnormalities are rare findings* - **Additional congenital abnormalities** are not rare; they are frequently associated with spina bifida, particularly with myelomeningocele. - These can include **hydrocephalus**, **Chiari malformations**, urinary tract anomalies, and orthopedic issues like clubfoot, reflecting a systemic developmental disruption.

Q: Simple febrile seizure is defined as

Generalized seizure <15 min, within 24 hours of fever onset, in a child 6mo-5yr. ***Generalized seizure <15 min, within 24 hours of fever onset, in a child 6mo-5yr*** - A **simple febrile seizure** is characterized by a **generalized tonic-clonic appearance**, lasting less than 15 minutes, and occurring within 24 hours of the onset of fever. - It typically affects children between the ages of **6 months and 5 years** who do not have a history of afebrile seizures or other neurological conditions. *All of the options* - This option is incorrect because simple febrile seizures must meet **specific criteria** regarding duration, number of episodes, and seizure type to be classified as simple. - While some individual components might be correct, the definition requires a **combination of specific features**, not a general 'all of the options' approach. *Seizure lasts < 15 min* - While a duration of less than 15 minutes is a **necessary criterion** for a simple febrile seizure, it is not sufficient on its own. - Other factors such as the type of seizure (generalized), the number of seizures (single in 24 hours), and the child's age are also crucial for the definition. *Focal seizure* - A **focal seizure**, characterized by originating in a specific area of the brain and often manifesting with localized symptoms, is a hallmark of a **complex febrile seizure**, not a simple one. - Simple febrile seizures are by definition **generalized**, meaning they affect both sides of the brain from the outset.

Q: A child presents with an open anterior fontanelle and an audible cranial bruit. Imaging reveals a midline lesion in the brain. What is the most likely diagnosis?

Malformation of vein of Galen. ***Malformation of vein of Galen*** - A **malformation of the vein of Galen** is a type of arteriovenous malformation that can cause greatly increased blood flow, leading to heart failure and a characteristic intracranial **bruit** audible over the skull. - The increased blood flow and often associated hydrocephalus can lead to **macrocephaly** and delayed closure of the **anterior fontanelle**. *Down syndrome* - While individuals with **Down syndrome** may have cardiac defects, a prominent intracranial bruit is not a typical feature unless associated with another condition. - The primary diagnostic features relate to distinct facial features, intellectual disability, and specific chromosomal abnormalities, not primarily a cranial bruit or specific midline brain lesion with this presentation. *Rickets* - **Rickets** is a bone disorder caused by vitamin D deficiency, leading to softening and weakening of bones, which can cause delayed fontanelle closure. - However, rickets does not cause a **cranial bruit** or a specific **midline brain lesion** as described. *Congenital hydrocephalus* - **Congenital hydrocephalus** can cause a persistently open **anterior fontanelle** and can lead to **macrocephaly** due to increased intracranial pressure. - However, a prominent **bruit** is not a characteristic feature of hydrocephalus itself; if a bruit is present, it suggests an underlying vascular anomaly like a vein of Galen malformation as the cause.

Question 1

The common type of cerebral palsy seen in hospitals is –

Accepted Answer

Spastic

Answer

Diplegia

Answer

Quadriplegia

Answer

Monoplegia

Question 2

Which of the following electrolyte abnormalities is a cause of status epilepticus in a child?

Accepted Answer

Hyponatremia

Answer

Hypokalemia

Answer

Hyperkalemia

Answer

Hypernatremia

Question 3

What is the drug of choice for acute treatment of febrile seizures?

Accepted Answer

Diazepam

Answer

Phenobarbitone

Answer

Valproate

Answer

Carbamazepine

Question 4

A 15-year-old boy presented with day dreaming and decline in school performance. The likely possibility is?

Accepted Answer

Typical absence seizure

Answer

Atonic seizure

Answer

Myoclonic seizure

Answer

Atypical absence seizure

Question 5

Febrile seizure is called as 'complex' when it lasts for?

Accepted Answer

> 15 minutes

Answer

> 30 minutes

Answer

> 5 minutes

Answer

> 10 minutes

Question 6

A pediatric patient with progressively developing degenerative neurologic disease/disorder has an elevated CSF antibody titer to measles virus. You should suspect which of the following?

Accepted Answer

Possible subacute sclerosing panencephalitis (SSPE)

Answer

Acute Lyme disease

Answer

Fifth disease

Answer

Possible hepatitis B infection

Question 7

According to current AAP guidelines, which of the following scenarios would be considered a relative indication for continuous antiepileptic prophylaxis in febrile seizures (though still generally not recommended)?

Accepted Answer

Febrile seizures lasting more than 30 minutes

Answer

3 or more febrile seizures in 6 months

Answer

6 or more febrile seizures in 1 year

Answer

Febrile seizures requiring pharmacotherapy to control seizures.

Question 8

Which of the following statements concerning spina bifida is True?

Accepted Answer

Spina bifida occulta occurs most often at L5-S1 level

Answer

Chromosomal abnormalities can be identified in approximately 50% of patients

Answer

A myelomeningocele is the most common type of spina bifida

Answer

Additional congenital abnormalities are rare findings

Question 9

Simple febrile seizure is defined as

Accepted Answer

Generalized seizure <15 min, within 24 hours of fever onset, in a child 6mo-5yr

Answer

All of the options

Answer

Seizure lasts < 15 min

Answer

Focal seizure

Question 10

A child presents with an open anterior fontanelle and an audible cranial bruit. Imaging reveals a midline lesion in the brain. What is the most likely diagnosis?

Accepted Answer

Malformation of vein of Galen

Answer

Down syndrome

Answer

Rickets

Answer

Congenital hydrocephalus

Neurology — MCQs

Neurology — MCQs

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