Gastroenterology Practice Questions

Q: All of the following are causes of blood in stools in children except?

Carcinoma. **Explanation:** The correct answer is **B. Carcinoma**. In the pediatric age group, gastrointestinal malignancies like colorectal carcinoma are exceedingly rare. While they can cause hematochezia in adults, they are not considered a standard differential diagnosis for blood in stools in children unless there is a strong genetic predisposition (e.g., Familial Adenomatous Polyposis). **Analysis of Options:** * **Meckel’s Diverticulum:** This is the most common cause of **painless, profuse lower GI bleeding** in toddlers. It contains ectopic gastric mucosa which secretes acid, leading to ulceration of the adjacent ileal mucosa. * **Intussusception:** Characteristically presents in infants (6–18 months) with a triad of colicky abdominal pain, a palpable sausage-shaped mass, and **"red currant jelly" stools** (a mixture of mucus and blood due to venous congestion). * **Juvenile Polyp:** These are benign hamartomatous polyps and represent the most common cause of **painless bright red streaks of blood** over the surface of stools in children aged 2–10 years. **Clinical Pearls for NEET-PG:** * **Most common cause of GI bleed in neonates:** Swallowed maternal blood (Apt test is used to differentiate). * **Most common cause of lower GI bleed in infants:** Anal fissures or Milk Protein Allergy. * **Rule of 2s (Meckel’s):** 2% of the population, 2 inches long, 2 feet from the ileocecal valve, 2 types of ectopic tissue (gastric/pancreatic), and presents by age 2. * **Investigation of choice for Meckel’s:** Technetium-99m pertechnetate scan (Meckel’s scan).

Q: Which of the following is a sign of severe dehydration in a child?

Lethargy. In Pediatrics, dehydration is classified by the WHO into three categories: **No Dehydration**, **Some Dehydration**, and **Severe Dehydration**. This classification is a high-yield topic for NEET-PG. ### **Why Lethargy is Correct** **Lethargy** (or being unconscious) is a hallmark sign of **Severe Dehydration**. It indicates significant intravascular volume depletion leading to cerebral hypoperfusion. According to WHO guidelines, a child must have at least two of the following to be classified as severely dehydrated: 1. Lethargy or unconsciousness 2. Inability to drink or drinking poorly 3. Sunken eyes 4. Very slow skin pinch (returns in >2 seconds) ### **Why Other Options are Incorrect** * **Irritability (B):** This is a sign of **Some Dehydration**. As dehydration progresses to "Severe," the child’s sensorium worsens from irritability to lethargy. * **Increased duration of skin pinch (C):** While a "slow" skin pinch is seen in "Some Dehydration," the specific sign for "Severe Dehydration" is a **"very slow"** skin pinch (taking more than 2 seconds). * **Sunken eyes (D):** This sign is common to both **Some** and **Severe Dehydration**. Since "Lethargy" is specific only to the Severe category, it is the more definitive answer for severity. ### **Clinical Pearls for NEET-PG** * **Plan C:** Severe dehydration is treated with IV fluids (Ringer’s Lactate is the fluid of choice). * **The "Skin Pinch" (Skin Turgor):** In children with **Severe Acute Malnutrition (SAM)** or **hypernatremic dehydration**, the skin pinch test is unreliable. * **Key Differentiator:** If a child is "Restless/Irritable," think **Some Dehydration**. If the child is "Lethargic/Floppy," think **Severe Dehydration**.

Q: A child with diarrhea was eager to drink, and the skin pinch went back slowly. Which of the following categories is the child classified into as per IMNCI?

Yellow. ***Yellow***- This classification applies when the child shows two or more signs of **'Some Dehydration'** according to IMNCI guidelines, which include **eagerly drinking/thirst** and the **skin pinch going back slowly** (less than 2 seconds but noticeably delayed).- The management for the Yellow category involves treating dehydration using **Oral Rehydration Salts (ORS)** (Plan B).*Pink*- The **Pink (Severe Dehydration) category** requires at least two signs such as **lethargy/unconsciousness**, inability to drink/drinking poorly, or the **skin pinch going back very slowly** (≥ 2 seconds).- The child is **eager to drink**, which rules out the severe dehydration sign of being **unable to drink** or **drinking poorly**.*Green*- The **Green (No Dehydration) category** is applied when the child does not exhibit sufficient signs to classify them into the 'Some' or 'Severe' dehydration categories.- Since the child demonstrates two definite signs of dehydration (**thirst** and **slow skin pinch**), the 'No Dehydration' classification is incorrect.*None*- IMNCI provides specific and comprehensive categories (**Green, Yellow, Pink**) for classifying dehydration status based on clinical signs.- The combination of **eager drinking** and **slow skin pinch** definitively places the child in the **Yellow (Some Dehydration)** category.

Q: A 2-week-old infant presents with high conjugated (direct) bilirubin, dark-colored urine, and clay-colored stools. On examination, the infant appears jaundiced, but is feeding normally. What is the most likely diagnosis?

Biliary atresia. ***Biliary atresia*** - High **conjugated hyperbilirubinemia** combined with characteristic signs of biliary obstruction, such as **acholic (clay-colored) stools** and **dark urine**, is the classic presentation of **biliary atresia** in infants typically presenting after the first week of life. - This condition involves progressive obliteration of the extrahepatic **biliary tree**, requiring urgent diagnosis and treatment (Kasai procedure) before 60 days of age to prevent irreversible **cirrhosis**. *Crigler-Najjar syndrome* - This disorder results from a severe deficiency or absence of **UGT1A1** activity, leading exclusively to severe **unconjugated hyperbilirubinemia** and a high risk of **kernicterus**. - It does not involve excretion issues causing **conjugated hyperbilirubinemia** or evidence of biliary blockage like **acholic stools**. *Gilbert's syndrome* - This syndrome is characterized by **unconjugated hyperbilirubinemia** due to reduced activity of the hepatic enzyme **UDP-glucuronosyltransferase (UGT1A1)**, not the conjugated form seen here. - It is generally an inherited, benign condition that presents later in life (adolescence/adulthood) and does not cause **biliary obstruction** symptoms (clay stools, dark urine). *Physiological jaundice* - **Physiological jaundice** typically presents with **unconjugated hyperbilirubinemia**, begins *after* 24 hours of life, peaks around 3-5 days, and usually resolves by 1-2 weeks. - The presentation at 2 weeks with *conjugated* hyperbilirubinemia (which is always pathological) and signs of obstruction rules out this benign, self-limiting cause.

Q: A child presents with abdominal distension and an enlarged liver by 8cm below the costal margin. The liver is smooth on palpation. Which of the following is the most likely diagnosis?

Glycogen Storage Disease (GSD). ***Glycogen Storage Disease (GSD)***- GSDs, particularly Type I (**Von Gierke Disease**), cause massive, **smooth hepatomegaly** due to the accumulation of normal or abnormal glycogen within hepatocytes.- The presentation in childhood with severe abdominal distension and an enlarged, non-tender, **smooth liver** is highly characteristic of these metabolic disorders.*Lysosomal Storage Disease (LSD)*- While LSDs (e.g., Gaucher, Niemann-Pick) can cause hepatomegaly, they often involve the **Reticuloendothelial system**, leading to prominent **splenomegaly** as well, which is not mentioned here.- Clinical features usually include severe **neurological impairment** or **skeletal abnormalities**, differentiating them from GSDs which primarily affect the liver and glucose metabolism initially.*Hepatocellular Carcinoma (HCC)*- HCC usually results in a **firm, nodular, or irregular** liver surface on palpation, reflecting tumor growth, rather than a uniformly smooth enlargement.- Although rare in children, when it occurs, it is typically associated with rapidly worsening symptoms, weight loss, and often underlying conditions like **cirrhosis** or **hepatitis**.*Autoimmune Hepatitis*- This condition involves chronic **inflammation and destruction of hepatocytes**, often leading to symptoms of liver failure (jaundice) and elevated **transaminases**.- Long-standing autoimmune hepatitis progresses to cirrhosis, resulting in a **fibrotic or nodular** liver, rarely presenting as primary, massive, smooth hepatomegaly in a child.

Q: A 5 year old boy presented with hematemesis and was found to have splenomegaly, on examination. There was a past history of exchange transfusion in this child for neonatal jaundice. What is the probable diagnosis?

Portal vein thrombosis. ***Portal vein thrombosis***- This is the most probable diagnosis because **extrahepatic portal vein thrombosis (EHPVO)** is the most common cause of portal hypertension and variceal bleeding in pediatric patients.- A past history of **exchange transfusion** (which often utilizes umbilical vein catheterization) is a major risk factor for initiating ascending thrombophlebitis that leads to the development of a **portal vein thrombus**.- Manifestations include **splenomegaly** (due to portal hypertension) and **hematemesis** (due to bleeding from esophageal varices).*Splenic vein thrombosis*- **Isolated splenic vein thrombosis** causes *segmental portal hypertension*, typically resulting in localized high pressure leading mainly to **isolated gastric varices**.- While it causes **splenomegaly**, it is less likely to cause the severe, diffuse portal hypertension and extensive esophageal varices responsible for large-volume hematemesis seen in EHPVO.*Budd-Chiari syndrome*- This syndrome involves obstruction of the **hepatic veins** (or suprahepatic inferior vena cava), leading acutely to symptoms like tender **hepatomegaly**, intractable ascites, and often signs of **liver failure**.- The patient's presentation is characterized by isolated signs of *pre-hepatic portal hypertension* (splenomegaly and variceal bleeding), not the typical constellation of liver congestion seen in Budd-Chiari.*Liver cirrhosis*- Although cirrhosis causes portal hypertension, the history in a 5-year-old points toward a specific **pre-hepatic vascular etiology** (PVT) secondary to a neonatal event rather than a parenchymal disease.- Cirrhosis usually is accompanied by signs of chronic liver failure, such as **jaundice**, **synthetic dysfunction**, or **ascites**, which are absent in this typical EHPVO presentation.

Q: A 2-week-old neonate was brought to the hospital with a complaint of non-bilious vomiting. While examining the baby, the physician noted a lump in the right upper quadrant, which showed movement while feeding. What is the likely diagnosis of this child?

IHPS. ***Correct: IHPS (Infantile Hypertrophic Pyloric Stenosis)*** - Classic presentation: **2-8 weeks old neonate** with progressive **non-bilious projectile vomiting** - Hallmark finding: **Palpable olive-shaped mass in right upper quadrant** (hypertrophied pyloric muscle) - **Visible peristaltic waves** from left to right upper abdomen, especially after feeding - Associated with **hypochloremic hypokalemic metabolic alkalosis** - Treatment: Ramstedt pyloromyotomy *Incorrect: Duodenal atresia* - Presents within **first day of life** (not at 2 weeks) - Causes **bilious vomiting** (obstruction distal to ampulla of Vater) - "Double bubble" sign on X-ray - Associated with Down syndrome *Incorrect: Esophageal atresia* - Presents **immediately after birth** with drooling and choking - No palpable abdominal mass - Diagnosed with **inability to pass nasogastric tube** - Often associated with tracheoesophageal fistula (TEF) *Incorrect: Intussusception* - Typical age: **6-36 months** (not neonates) - Presents with **colicky abdominal pain** and "currant jelly" stools - Palpable "sausage-shaped" mass in right upper quadrant - Treatment: Air/hydrostatic reduction

Q: Which of the following is not true about CHPS? CHPS - Congenital hypertrophic pyloric stenosis

b.Caused by hypertrophy of longitudinal muscles. ***b.Caused by hypertrophy of longitudinal muscles***- The defining pathology of congenital hypertrophic pyloric stenosis involves hypertrophy and hyperplasia of the **circular muscle layer** of the pylorus, not the longitudinal muscle layer.- This thickening of the circular muscle narrows the pyloric canal lumen, leading to gastric outlet obstruction.*a.Presents with non-bilious vomiting*- This is a true statement; vomiting is typically **non-bilious** because the obstruction is proximal to the **ampulla of Vater** (where bile enters the duodenum).- The vomiting is often projectile, feeding soon after a meal, and progresses from occasional to nearly every feed.*c.USG is very sensitive in diagnosing this condition*- This is a true statement; ultrasonography is the diagnostic modality of choice due to its high sensitivity and specificity, avoiding radiation exposure.- Diagnosis is confirmed when the **pyloric muscle wall thickness** is >4 mm or the **pyloric channel length** is >16 mm.*d.Hypokalemic metabolic alkalosis seen*- This is a true statement; persistent, massive vomiting leads to the loss of gastric **hydrochloric acid (HCl)**.- The resulting primary loss of H+ ions leads to **metabolic alkalosis**, which is compensated by renal excretion of K+ and retention of HCO3- (leading to secondary **hypokalemia**).

Q: A 6-week-old infant presents with a history of non-bilious, non-projectile vomiting starting at 3 weeks of age. The infant's abdominal examination is normal. Which of the following is the most likely diagnosis?

Gastroesophageal reflux disease (GERD). ***Gastroesophageal reflux disease (GERD)*** - This is the most common cause of non-bilious, **non-projectile** vomiting (regurgitation) in healthy infants, often starting early and peaking around 4-5 months of age. - The history is consistent with simple **physiologic reflux**, characterized by non-forceful spitting up and a **normal abdominal examination**. *Pyloric stenosis* - Classically involves **projectile** non-bilious vomiting that becomes progressively worse, which contradicts the non-projectile description. - A physical exam would typically reveal an **olive-like mass** (hypertrophied pylorus) or visible gastric peristalsis, which is stated to be absent. *Cow Milk Protein Allergy* - Although vomiting can occur, it is usually accompanied by other symptoms like **bloody stools**, severe irritability, or **eczema**, which are not mentioned. - Isolated, mild, non-projectile vomiting without systemic signs is less specific for a protein allergy than for GERD. *Intestinal obstruction* - Obstruction distal to the ampulla of Vater (e.g., malrotation, atresia) typically causes **bilious vomiting**, which is absent in this case. - Such conditions usually lead to an **abnormal abdominal examination** or signs of acute illness, which are not present here.

Q: A 4-week-old baby presents with non-bilious vomiting and abdominal distension. The radiological image is shown. Among the clinical features, which is the most essential finding in reaching the diagnosis of this condition?

Palpation of lump. ***Palpation of lump*** - In pyloric stenosis, the hypertrophied pylorus can often be palpated as an **olive-shaped mass** in the right upper quadrant or epigastrium. - This palpable mass upon abdominal examination is considered the most **crucial diagnostic finding** for pyloric stenosis. *Visible peristalsis* - While **visible peristaltic waves** (particularly from left to right across the epigastrium) can be a sign of pyloric stenosis, they are not specific or the most essential diagnostic feature. - Visible peristalsis indicates an attempt by the stomach to force contents past an obstruction, but its presence can vary and may not be consistently observed. *Projectile vomiting* - **Projectile non-bilious vomiting** is a classic symptom of pyloric stenosis, suggesting a significant outflow obstruction. - However, symptoms alone are not as definitive for diagnosis as the physical finding of the "olive-shaped" mass, as other conditions can also cause severe vomiting. *Loss of weight and dehydration* - **Weight loss** and **dehydration** are common consequences of persistent vomiting due to pyloric stenosis, indicating disease progression. - These are systemic effects reflecting the severity of the condition rather than a direct diagnostic feature of the underlying anatomical abnormality.

Question 1

All of the following are causes of blood in stools in children except?

Accepted Answer

Carcinoma

Answer

Meckel's diverticulum

Answer

Intussusception

Answer

Juvenile polyp

Question 2

Which of the following is a sign of severe dehydration in a child?

Accepted Answer

Lethargy

Answer

Irritability

Answer

Increased duration of skin pinch

Answer

Sunken eyes

Question 3

A child with diarrhea was eager to drink, and the skin pinch went back slowly. Which of the following categories is the child classified into as per IMNCI?

Accepted Answer

Yellow

Answer

Green

Answer

None

Answer

Pink

Question 4

A 2-week-old infant presents with high conjugated (direct) bilirubin, dark-colored urine, and clay-colored stools. On examination, the infant appears jaundiced, but is feeding normally. What is the most likely diagnosis?

Accepted Answer

Biliary atresia

Answer

Crigler-Najjar syndrome

Answer

Gilbert’s syndrome

Answer

Physiological jaundice

Question 5

A child presents with abdominal distension and an enlarged liver by 8cm below the costal margin. The liver is smooth on palpation. Which of the following is the most likely diagnosis?

Accepted Answer

Glycogen Storage Disease (GSD)

Answer

Autoimmune Hepatitis

Answer

Hepatocellular Carcinoma (HCC)

Answer

Lysosomal Storage Disease (LSD)

Question 6

A 5 year old boy presented with hematemesis and was found to have splenomegaly, on examination. There was a past history of exchange transfusion in this child for neonatal jaundice. What is the probable diagnosis?

Accepted Answer

Portal vein thrombosis

Answer

Splenic vein thrombosis

Answer

Liver cirrhosis

Answer

Budd-Chiari syndrome

Question 7

A 2-week-old neonate was brought to the hospital with a complaint of non-bilious vomiting. While examining the baby, the physician noted a lump in the right upper quadrant, which showed movement while feeding. What is the likely diagnosis of this child?

Accepted Answer

IHPS

Answer

Duodenal atresia

Answer

Esophageal atresia

Answer

Intusussception

Question 8

Which of the following is not true about CHPS? CHPS - Congenital hypertrophic pyloric stenosis

Accepted Answer

b.Caused by hypertrophy of longitudinal muscles

Answer

a.Presents with non-bilious vomiting

Answer

c.USG is very sensitive in diagnosing this condition

Answer

d.Hypokalemic metabolic alkalosis seen

Question 9

A 6-week-old infant presents with a history of non-bilious, non-projectile vomiting starting at 3 weeks of age. The infant's abdominal examination is normal. Which of the following is the most likely diagnosis?

Accepted Answer

Gastroesophageal reflux disease (GERD)

Answer

Cow Milk Protein Allergy

Answer

Intestinal obstruction

Answer

Pyloric stenosis

Question 10

A 4-week-old baby presents with non-bilious vomiting and abdominal distension. The radiological image is shown. Among the clinical features, which is the most essential finding in reaching the diagnosis of this condition?

Accepted Answer

Palpation of lump

Answer

Visible peristalsis

Answer

Projectile vomiting

Answer

Loss of weight and dehydration

Gastroenterology — MCQs

Gastroenterology — MCQs

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