Reproductive Pathology — MCQs

Frozen section examination demonstrates fibrosis and cystic spaces. Also seen are areas of compressed glands with a lobular orientation. The glands are lined by a single layer of epithelial cells with oval nuclei and regular arrangement. No true invasion of glands into the adjacent stroma is seen. What is the most likely diagnosis?

E-cadherin mutation is seen in the metastasis of which type of breast carcinoma?

Testicular teratoma in adults is generally considered?

Which testicular tumor has the best prognosis?

Extramammary Paget's disease is typically seen in which of the following locations?

A 45-year-old woman develops abdominal and pelvic discomfort. Physical examination reveals a large mass in the right lower quadrant, which is surgically resected. The mass consists of a large (25 cm) cystic sac containing thick mucinous fluid within a thin wall. On careful inspection, the pathologist finds an area of increased thickness in the cyst wall, which is sampled for histology. Microscopically, the tumor appears to be composed mostly of a single layer of nonciliated columnar cells arranged in papillary projections. The thickened area, however, displays stratification of epithelial cells, increased cytologic atypia, and high mitotic activity. Nevertheless, no stromal invasion is found. Which of the following is the most likely diagnosis?

Intrauterine exposure of diethylstilbestrol is associated with which of the following conditions?

Which of the following is a testicular tumor marker?

A 67-year-old male is found on rectal examination to have a single, hard, irregular nodule within his prostate. A biopsy of this lesion reveals the presence of small glands lined by a single layer of cells with enlarged, prominent nucleoli. From what region of the prostate did this lesion most likely originate?

A 25-year-old man presents 1 week after discovering that his left testicle is twice the normal size. Physical examination reveals a nontender, testicular mass that cannot be transilluminated. Serum levels of alpha-fetoprotein and human chorionic gonadotropin are normal. A hemiorchiectomy is performed, and histologic examination of the surgical specimen shows neoplastic cells with an epithelial appearance, growing in alveolar or tubular patterns, exhibiting hyperchromatic nuclei with prominent nucleoli. Compared to normal adult somatic cells, this germ cell neoplasm would most likely show high levels of expression of which of the following proteins?