Neuropathology — MCQs

Neurodegeneration with iron accumulation in basal ganglia is typically seen in which condition?

What is the most common primary brain tumor in adults?

Rupture of Berry aneurysm causes which type of hemorrhage?

Small cystic lesions in the lenticular nucleus, thalamus, and internal capsule are most closely associated with what condition?

Which of the following statements is FALSE regarding Krabbe's disease?

What is the most common type of pathological change seen in Rabies?

What is a watershed infarct in the brain?

A 12-year-old boy develops fever, accompanied by occasional headaches, malaise, fatigue, and nausea a month after being bitten by a dog. One day later, he experiences episodes of rigidity, hallucinations, breath-holding, and difficulty swallowing because of uncontrollable oral secretions. Considering this clinical presentation and the historical context of early rabies treatment attempts, which of the following histologic findings in the brain would be most likely present in a rabid animal?

A 30-year-old woman suffers a tonic-clonic seizure and presents with delirium and hydrophobia after being bitten on the hand by a bat approximately one month prior. The patient subsequently dies of respiratory failure. Autopsy reveals viral particles throughout the brainstem and cerebellum. In addition to direct viral cytotoxicity, by which primary mechanism is the necrosis of virally infected neurons mediated in this patient?

A 42-year-old immunosuppressed male presents with rapidly progressing neurologic symptoms including mental deterioration, visual loss, abnormal speech, and ataxia. Radiographic studies demonstrate multifocal lesions in the white matter without mass effect. A stereotactic brain biopsy reveals areas of demyelination. Which histologic feature is most likely to be present in this patient?