Neuropathology — MCQs

A 42-year-old man presents with worsening involuntary jerky movements, depression, and progressive dementia. He dies within several years, and autopsy reveals bilateral atrophy of the caudate nuclei. What is the basic abnormality involved in this individual's disease process?

A 42-year-old woman gives birth to a neonate with multiple congenital abnormalities including a flat facial profile, slanted eyes, epicanthal folds, Brushfield spots, short nose, short neck, dysplastic ears, clinodactyly, a large protruding tongue, and a pronounced heart murmur. As an adult, the brain of this patient will show histopathologic changes characteristic of which of the following neurologic diseases?

All of the following are common sites of a berry aneurysm, EXCEPT:

Which area of the brain most commonly undergoes atrophy in Alzheimer's disease?

Which protein is primarily associated with Alzheimer's disease?

An immunocompromised person presents with a history of seizures and an MRI revealing a temporal lobe lesion. Brain biopsy results showed multinucleated giant cells with intranuclear inclusions. What is the most probable cause of the lesion?

Kernohan-Woltman sign (notch) is seen in which type of brain herniation?

All of the following are true regarding primary CNS lymphoma, except:

Multiple cystic lesions are seen in the muscle and brain of a 16-year-old boy who died of status epilepticus. What is the most likely diagnosis?

Aggregates of 'tau protein' seen in the Hippocampus of an elderly man are indicative of which of the following?