Neoplasia Practice Questions

Q: Beta-naphthyl amine dyes predispose to which carcinoma?

Urinary bladder carcinoma. **Explanation:** **Beta-naphthylamine** is a classic aromatic amine used historically in the rubber, dye, and chemical industries. It is a potent **procarcinogen** that undergoes metabolism in the liver (via N-oxidation) and is subsequently excreted in the urine. Once in the bladder, the acidic environment and the enzyme beta-glucuronidase convert it into its active carcinogenic form, which directly damages the DNA of the urothelium. This process leads to the development of **Urinary Bladder Carcinoma**, specifically **Transitional Cell Carcinoma (TCC)**. **Analysis of Options:** * **Urinary Bladder Carcinoma (Correct):** The bladder is the primary site because the active metabolites of aromatic amines (like beta-naphthylamine and benzidine) are concentrated and stored in the urine, allowing for prolonged contact with the bladder wall. * **Renal Carcinoma:** While some chemicals affect the kidneys, Renal Cell Carcinoma (RCC) is more strongly associated with smoking, obesity, and genetic syndromes (like VHL) rather than specific dye exposure. * **Hepatic Carcinoma:** Associated primarily with Aflatoxins, Hepatitis B/C, and Vinyl chloride (angiosarcoma), not naphthylamine dyes. * **Lung Carcinoma:** Primarily linked to tobacco smoke, asbestos, radon, and arsenic. **High-Yield Clinical Pearls for NEET-PG:** * **Occupational Risk:** Workers in the dye, rubber, leather, and textile industries are at the highest risk. * **Latency Period:** There is a long lag period (often 15–40 years) between exposure and the development of bladder cancer. * **Other Risk Factors for Bladder Cancer:** Smoking (most common), *Schistosoma haematobium* (linked to Squamous Cell Carcinoma), and drugs like Cyclophosphamide (linked to TCC). * **Screening:** Periodic urine cytology is recommended for workers with high-risk occupational exposure.

Question 1

All of the following are inhibitors of cell cycle progression except?

Accepted Answer

CDK2

Answer

P21

Answer

P27

Answer

p16INK4a

Question 2

Which of the following is NOT a hormonal tumor marker?

Accepted Answer

Neuron-specific enolase

Answer

b-HCG

Answer

Calcitonin

Answer

Catecholamine

Question 3

Metastasis to the liver is uncommon with which of the following malignancies?

Accepted Answer

Prostate

Answer

Colon

Answer

Lung

Answer

Breast

Question 4

Beta-naphthyl amine dyes predispose to which carcinoma?

Accepted Answer

Urinary bladder carcinoma

Answer

Renal carcinoma

Answer

Hepatic carcinoma

Answer

Lung carcinoma

Question 5

In which of the following malignancies is the histological grade a good prognostic indicator?

Accepted Answer

Soft tissue sarcoma

Answer

Renal cell carcinoma

Answer

Papillary thyroid carcinoma

Answer

Hepatoma

Question 6

Which of the following is NOT a chemical carcinogen?

Accepted Answer

Beta carotene

Answer

Benzene

Answer

Thorotrast

Answer

Nitrates

Question 7

Which of the following is a marker for squamous cell carcinoma?

Accepted Answer

Cytokeratin

Answer

Vimentin

Answer

Desmin

Answer

Myogenin

Question 8

A 68-year-old man with a history of metastatic prostate cancer presents with significant weight loss, loss of appetite, and loss of energy over the past 2 months. Which of the following is most likely responsible for his current spectrum of conditions?

Accepted Answer

Tumor necrosis factor-alpha

Answer

Platelet-derived growth factor

Answer

Fibroblast growth factor

Answer

Interleukin-2

Question 9

Which one of the following is a benign tumor?

Accepted Answer

All of the above

Answer

Atheroma

Answer

Granuloma

Answer

Papilloma

Question 10

What is the nature of a hamartoma?

Accepted Answer

Non-neoplastic

Answer

Neoplastic

Answer

Afflicted by trauma

Answer

Hormonal disturbance

Neoplasia — MCQs

Neoplasia — MCQs

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