Gastrointestinal Pathology — MCQs

Creeping fat is a characteristic feature of which of the following conditions?

A 44-year-old woman presents with increasing abdominal distention over the past 6 weeks. Physical examination reveals an abdominal fluid wave and present bowel sounds. Paracentesis yields 1000 mL of slightly cloudy serous fluid containing malignant cells consistent with adenocarcinoma. Molecular analysis of these cells shows an MSH2 gene mutation with microsatellite instability. Her medical history is otherwise unremarkable. Her sister was diagnosed with endometrial cancer, and her brother had gastric carcinoma. What is the most likely diagnosis explaining this patient's symptoms?

A 24-year-old woman gives birth to a term infant after an uncomplicated pregnancy. Apgar scores are 9 and 10 at 1 and 5 minutes after birth. The infant's length and weight are at the 55th percentile. There is no significant passage of meconium. Three days after birth, the infant vomits all oral feedings. On physical examination, the infant is afebrile, but the abdomen is distended and tender, and bowel sounds are reduced. An abdominal ultrasound scan shows marked colonic dilation above a narrow segment in the distal sigmoid region. A biopsy specimen from the narrowed region shows an absence of ganglion cells in the muscle wall and submucosa. Which of the following is most likely to produce these findings?

Mutation of the STK11 and LKB1 gene is associated with which of the following conditions?

Gluten-sensitive enteropathy is most strongly associated with which HLA haplotype?

Which of the following tumors is of salivary gland origin?

Which of the following is produced by argentaffinoma of the ileum?

Adenocarcinoma in the esophagus most commonly occurs in which region?

Lymphoepithelial change in the stomach is seen in which condition?

A 40-year-old woman presents with a 2-month history of burning epigastric pain that usually occurs between meals. The pain can be relieved with antacids or food. The patient also reports a recent history of tarry stools. She denies taking aspirin or NSAIDs. Laboratory studies show a microcytic, hypochromic anemia (serum hemoglobin = 8.5 g/dL). Gastroscopy reveals a bleeding mucosal defect in the antrum measuring 1.5 cm in diameter. An endoscopic biopsy shows that the lesion lacks mucosal lining cells and is composed of amorphous, cellular debris and numerous neutrophils. Which of the following is the most important factor in the pathogenesis of this patient's disease?