Endocrine Pathology — MCQs

A 10-year-old male child with short stature presents with complaints of frequent headaches over the past 6 months, slowly progressive loss of vision of the right eye, difficulty in walking, frequent mood changes, and excessive thirst. MRI brain showed a tumor in the sellar region, which was resected. HPE examination showed reticular epithelial cells with appearances reminiscent of the enamel pulp of developing teeth, along with calcifications and wet keratin nodules. The gene involved in causing this condition is also involved in causing which other condition?

Mutation in which of the following genes is most commonly associated with medullary thyroid carcinoma?

A patient presents with weight gain, thinning of hair, and dry skin. Diagnosis is Hashimoto’s thyroiditis. Which antibody is seen in this case?

What is the primary mechanism behind tissue damage in long-standing diabetes?

Histopathological examination showed follicular cells with abundant pink eosinophilic cytoplasm WITHOUT nuclear grooves or ground-glass nuclei. This is most characteristic of?

A 45-year-old male presents with a neck mass. Fine needle aspiration shows pleomorphic cells with grooved nuclei (coffee bean appearance), nuclear pseudoinclusions, and psammoma bodies. What is the most likely diagnosis?

A patient presents with a mass in the front of the neck, along with odynophagia and dyspnea. Histopathology reveals tumor cells positive for TTF-1, synaptophysin, and chromogranin, and there is evidence of amyloid deposition. What is the most likely diagnosis?

Osteitis fibrosa cystica is a feature of

Most common neoplasm of thyroid gland is:

Fine Needle Aspiration Cytology (FNAC) is NOT conclusive in which one of the following thyroid swellings?