Bone and Soft Tissue Pathology — MCQs

A 10-year-old child presents with a predisposition to fractures, anemia, hepatosplenomegaly, and diffusely increased radiographic density of bones. What is the most likely diagnosis?

Severe laxity of joints is a characteristic feature of which of the following conditions?

Predominant osteoblastic secondaries are seen in which of the following malignancies?

Storiform pattern of tumor cells in histopathology is seen in which of the following tumors?

Histopathologically, reversal lines are seen in which of the following conditions?

A 55-year-old man presents with a five-month history of left thigh pain. Physical examination reveals the left thigh to be increased in size compared to the right. A plain film radiograph shows a 15 cm solid mass with infiltrative margins, not appearing to arise from bone. A biopsy of this mass reveals highly pleomorphic spindle cells on microscopic examination. Which of the following markers is most likely to be demonstrated in the cells of this mass?

MIC-2 is a marker of which condition?

Which of the following tumors has the propensity to metastasize through lymph nodes?

A 10-year-old girl presents with a tibial mass. Histopathological examination reveals a small round cell tumor. Which of the following molecular findings is most likely to be present?

A non-neoplastic hereditary bone lesion, histologically similar to central giant cell granuloma, affects children and shows a bilateral involvement of the jaws with 'eye to heaven' appearance clinically. What is this condition?