Bone and Soft Tissue Pathology — MCQs

What is the most common primary site for bony metastases?

In rheumatoid arthritis, where does the pathology typically begin?

A true cyst derived from the stellate reticulum and growing in place of a tooth is known as?

Which type of sarcoma is commonly seen in infancy?

A child presents with Ewing sarcoma. Histology shows it as one of the small round blue cell tumors. Which of the following accumulates in the cells of Ewing sarcoma?

Which of the following lesions has definite loculations and is multilocular in nature?

Dentinogenesis imperfecta differs from amelogenesis imperfecta in that, the former is characterized by calcification of pulp chambers and the root canals of the teeth?

What is the most common site for osteoma?

Which cancer most commonly metastasizes to the jaw bone?

A 75-year-old woman has experienced increasing dull but constant pain in the back, right chest, left shoulder, and left upper thigh for the past 6 months. She has now developed a sudden, severe, sharp pain in the left thigh. On physical examination, she has intense pain on palpation of the upper thigh, and the left leg is shorter than the right. A radiograph of the left leg shows a fracture through the upper diaphyseal region of the femur in a 5-cm lytic area that extends through the entire thickness of the bone. A bone scan shows multiple areas of increased uptake in the left femur, pelvis, vertebrae, right third and fourth ribs, upper left humerus, and left scapula. Laboratory studies show serum creatinine, 0.9 mg/dL; total protein, 6.7 g/dL; albumin, 4.5 g/dL; total bilirubin, 1 mg/dL; AST, 28 U/L; ALT, 22 U/L; and alkaline phosphatase, 202 U/L. What is the most likely diagnosis?