Contraception and Family Planning Practice Questions

Q: Yuzpe regimen should be administered within a maximum of -------

72 hours. ***72 hours*** - The **Yuzpe regimen**, an older form of emergency contraception, is most effective when initiated within **72 hours** (3 days) of unprotected intercourse. - It involves taking two doses of combined **estrogen and progestin pills 12 hours apart**. *3 hours* - This timeframe is too short for the general recommendation of the **Yuzpe regimen**, which has a wider window of effectiveness. - While earlier administration is better, 3 hours is not the maximum recommended time frame. *12 hours* - This timeframe incorrectly represents the recommended window for the **Yuzpe regimen**, which extends much longer. - 12 hours is often the interval between the two doses of the Yuzpe regimen, not the maximum time for the initial dose. *24 hours* - While administering the Yuzpe regimen within **24 hours** is highly effective, it is not the *maximum* time frame within which it can still be used. - The regimen's efficacy significantly decreases after 72 hours, but it can still be considered up to that point.

Q: Which of the following is NOT a mechanism of action of copper IUCDs?

Increase tubal motility. ***Increase tubal motility*** - Copper IUCDs (intrauterine contraceptive devices) prevent pregnancy primarily by creating a **sterile inflammatory reaction** in the uterus, making the environment hostile to sperm and eggs. - While they affect sperm and egg transport through the inflammatory response, **increasing tubal motility is NOT a recognized mechanism** of copper IUCDs. - The contraceptive effect is achieved through spermicidal action, prevention of fertilization, and interference with implantation. *Inhibit ovulation* - This is characteristic of **hormonal contraceptives** and **hormonal IUCDs (LNG-IUS)**, which can suppress the hypothalamic-pituitary-ovarian axis. - **Copper IUCDs** (non-hormonal) act locally within the uterus and do NOT inhibit ovulation. - Women using copper IUCDs continue to ovulate normally. *Induce biochemical changes in the endometrium* - Copper IUCDs release copper ions, which create a **spermicidal inflammatory reaction** in the uterus and fallopian tubes. - This reaction causes biochemical and morphological changes in the endometrium, making it unsuitable for sperm survival and fertilization. - The inflammatory environment is hostile to both sperm and eggs. *Inhibit implantation of the fertilized egg* - This is a key mechanism of action for copper IUCDs. - The local uterine inflammatory changes and endometrial alterations prevent a fertilized egg from successfully implanting in the **uterine wall**. - This is one of the primary contraceptive mechanisms of copper-containing devices.

Q: A depot contraceptive, DMPA, is to be given every:

3 months. ***3 months*** - **Depot medroxyprogesterone acetate (DMPA)**, commonly known as **Depo-Provera**, is a highly effective injectable contraceptive. - It works by preventing ovulation and thickening cervical mucus and is administered as an **intramuscular injection** every **12 to 13 weeks** (approximately 3 months). *1 month* - While some **combined oral contraceptives** and **vaginal rings** are used on a monthly cycle, DMPA is not [1]. - Administering DMPA monthly would result in unnecessarily high hormone levels and potential side effects. *2 months* - Administering DMPA every two months is not the standard dosing regimen for this contraceptive. - The efficacy and duration of action of DMPA are well-established for a 3-month interval. *6 months* - The contraceptive effect of DMPA typically lasts for about 3 months; therefore, waiting 6 months between injections would leave the user unprotected for a significant period. - Other long-acting reversible contraceptives (LARCs) like some **subdermal implants** or **intrauterine devices (IUDs)** can provide protection for longer periods, but not DMPA.

Q: Combined oral pills reduce the risk of?

Ovarian cancer. ***Ovarian cancer*** - Combined oral contraceptive pills reduce the risk of **ovarian cancer** by suppressing ovulation and reducing exposure of ovarian cells to incessant hormonal stimulation. - The longer the duration of use, the greater the protective effect, which can persist for years after discontinuation. *Breast cancer* - Some studies suggest a **slight increase in breast cancer risk** with current or recent use of combined oral contraceptives, especially in women with a family history or other risk factors. - However, this increased risk typically **reverts to baseline 10 years after cessation** of use. *Cervical cancer* - Long-term use of combined oral contraceptives is associated with a **modestly increased risk of cervical cancer**, particularly in women who are also infected with **human papillomavirus (HPV)**. - This increased risk is thought to be due to chronic inflammation or hormonal effects on the cervix, but it is **HPV infection that drives cervical cancer pathogenesis**. *Vaginal cancer* - Vaginal cancer is a **rare malignancy**, and combined oral contraceptives have generally **not been shown to either increase or decrease its risk**. - **Diethylstilbestrol (DES) exposure in utero** is the primary risk factor for a specific type of vaginal cancer, **clear cell adenocarcinoma**.

Q: Best long-acting reversible contraception (LARC) that can be inserted immediately postpartum in a lactating mother is:

Post Partum IUCD. ***Post Partum IUCD*** - **Intrauterine contraceptive devices (IUCDs)** are highly effective long-acting reversible contraceptives (LARC) that can be inserted **immediately postpartum** (within 10 minutes of placental delivery) or within 48 hours of delivery. - They are **safe for breastfeeding mothers** as copper IUCDs are non-hormonal and levonorgestrel-releasing IUCDs (LNG-IUS) have only localized hormonal effects. - **WHO MEC Category 1** for breastfeeding women, with no interference with lactation or infant growth. - Provide immediate, long-term protection (3-10 years depending on type) with high continuation rates. *Depot provera* - **Depot medroxyprogesterone acetate (DMPA)** is a progestin-only injectable contraceptive that is also safe for breastfeeding mothers (WHO MEC Category 1 after 6 weeks postpartum). - However, it is **not a LARC method that can be inserted immediately postpartum** - it requires injection and has a 3-month duration requiring repeat visits. - While effective for lactating women, it cannot be given in the immediate postpartum period like IUCD insertion. *Combined oral contraceptive pills (OCPs)* - **Combined OCPs** contain estrogen, which can **reduce milk supply** and alter milk composition, especially in the early postpartum period. - **WHO MEC Category 3-4** for breastfeeding women (depending on timing postpartum), contraindicated in the first 6 weeks and generally avoided during lactation. - Not recommended as first-line contraception for lactating mothers. *Calendar method* - The **calendar method** is a natural family planning method that relies on tracking menstrual cycles to predict fertile windows. - It is **highly unreliable** in the postpartum period due to unpredictable ovulation and irregular cycles, especially during breastfeeding (lactational amenorrhea makes cycle tracking impossible). - Not an effective contraceptive method for postpartum women.

Q: Spermicidal jelly acts through what mechanism?

Lysis of sperm cell membrane. ***Lysis of sperm cell membrane*** - Spermicidal jelly typically contains a chemical agent, most commonly **nonoxynol-9**, which acts as a **surfactant**. - This surfactant mechanism disrupts the **lipid bilayer of the sperm cell membrane**, leading to its rupture and cell death. *Acrosomal enzyme activity* - Spermicides do not primarily work by affecting **acrosomal enzymes**, which are crucial for fertilization by breaking down the egg's outer layers. - While sperm death would prevent acrosomal reaction, it's not the direct mechanism of action of spermicides. *Alteration of cervical mucus* - While some contraceptive methods, such as **progestin-only pills**, alter cervical mucus to impede sperm passage, this is not the primary mechanism of action for **spermicidal jelly**. - Spermicides aim to directly kill sperm rather than solely hindering their movement through the cervix. *Inhibition of glucose uptake by sperm* - Spermicides do not primarily function by inhibiting the **metabolic processes** of sperm, such as glucose uptake. - Their main action is a direct cytotoxic effect on the **sperm cell structure**.

Q: What is the hormonal contraceptive of choice in a lactating woman?

Progestin-only pill. ***Progestin-only pill*** - The **progestin-only pill** is generally considered the hormonal contraceptive of choice for lactating women because it does not negatively impact **milk supply** or the **growth of the infant**. - Progestin-only methods have minimal to no effect on the **quality or quantity of breast milk**. *Combined oral contraceptive* - **Combined oral contraceptives (COCs)** contain both estrogen and progestin, and the **estrogen component** can **reduce milk supply**. - Due to the potential for impacting lactation, COCs are generally **not recommended** for use in the early postpartum period while a woman is breastfeeding exclusively. *Centchroman (non-hormonal option)* - **Centchroman** is a non-hormonal contraceptive that functions as a **selective estrogen receptor modulator (SERM)**. While it is an oral contraceptive, it is not a hormonal choice in the same category as progestin-only or combined pills and is less commonly used as a first-line option specifically for lactating women over progestin-only methods. - While it may not affect lactation, it is **not the 'hormonal contraceptive of choice'** among the given options, and its efficacy and availability may vary. *Multiphasic oral contraceptive* - **Multiphasic oral contraceptives** are a type of combined oral contraceptive, meaning they contain both **estrogen and progestin**, with varying doses throughout the cycle. - Similar to other combined hormonal contraceptives, the **estrogen content** can **suppress milk production**, making it an unsuitable choice for lactating women.

Q: Which of the following is not typically used as an emergency contraceptive?

Estrogen. ***Estrogen*** - High-dose estrogen alone is **not typically used for emergency contraception** due to a high incidence of adverse effects (severe nausea and vomiting) and significantly lower effectiveness compared to progestin-only or selective progesterone receptor modulator methods. - The **Yuzpe method** (an older emergency contraceptive regimen) used **combined** oral contraceptives containing both estrogen and progestin, but estrogen alone has no role in modern emergency contraception. *Combined oral pills* - Certain combined oral contraceptive pills (containing both estrogen and progestin) can be used as **emergency contraception in specific dosages**, known as the **Yuzpe method**. - This method involves taking two doses of combined pills within 72 hours of unprotected intercourse, but it has largely been superseded by more effective and better-tolerated options. *Ulipristal acetate* - **Ulipristal acetate is a selective progesterone receptor modulator (SPRM)** that is highly effective as an emergency contraceptive. - It can be taken up to **120 hours (5 days)** after unprotected intercourse and is **more effective than levonorgestrel**, especially between 72-120 hours. - It works primarily by **delaying or inhibiting ovulation**. *Levonorgestrel* - **Levonorgestrel is the most widely used progestin-only emergency contraceptive pill**, typically taken as a single 1.5 mg dose or two 0.75 mg doses. - It is most effective when taken within **72 hours** of unprotected intercourse. - It primarily works by **delaying or inhibiting ovulation** and preventing fertilization.

Q: Which of the following tubal sterilization procedures is considered the least effective?

Hysteroscopic occlusion. ***Hysteroscopic occlusion*** - This method, using devices like the **Essure system** (discontinued in 2018), historically had higher reported failure rates and has been associated with more complications compared to surgical ligation methods. - Its effectiveness relies on adequate fibrosis around the device to block the fallopian tubes, which can take several months, and requires a **confirmation hysterosalpingogram (HSG)**. - Failure rates reported at **0.9-1.6%**, making it the least effective among standard tubal sterilization methods. *Laparoscopic Yoon's ring method* - Involves applying a **silastic band (Falope Ring or Yoon's Ring)** to a loop of the fallopian tube, causing necrosis and effective occlusion. - It is a highly effective method with a low failure rate of approximately **0.5%** when performed correctly. *Pomeroy's method* - Involves ligating and excising a section of the fallopian tube, widely recognized as one of the **most effective** and commonly performed tubal ligation techniques. - Its high success rate (failure rate **0.4%**) is due to the complete transection of the tube, creating a physical barrier to sperm and egg meeting. *Vaginal fimbriectomy* - This procedure involves the removal of the **fimbrial portion of the fallopian tube** via a vaginal approach, making it an effective sterilization method. - While effective, it is less commonly performed than laparoscopic methods and offers similar efficacy to other surgical ligation techniques.

Q: In the context of tubal ligation, what is the failure rate of Pomeroy's technique?

0.5-1%. ***0.5-1%*** - Pomeroy's technique generally has a reported **failure rate** in the range of **0.5% to 1% per 100 women-years**. - This rate indicates that despite being a highly effective method of sterilization, a small percentage of women may still experience **pregnancy** after the procedure. *0.1-0.5%* - This range is typically considered too low for the **failure rate** of Pomeroy's technique, which is known to have a slightly higher but still very effective rate. - While some highly effective contraceptive methods might approach this range, tubal ligation techniques like Pomeroy's have a small, but consistently reported, higher failure rate. *1-2%* - While still low, this range is generally considered to be a slightly **higher than average failure rate** for Pomeroy's technique. - An incidence in this range might suggest a technical issue during the procedure or a less effective method in general. *5-10%* - This range represents a significantly **higher failure rate** than what is typically associated with Pomeroy's technique, which is recognized as a very effective method of permanent sterilization. - A failure rate this high would be comparable to less effective or temporary contraceptive methods, rather than a surgical sterilization procedure.

Question 1

Yuzpe regimen should be administered within a maximum of -------

Accepted Answer

72 hours

Answer

3 hours

Answer

12 hours

Answer

24 hours

Question 2

Which of the following is NOT a mechanism of action of copper IUCDs?

Accepted Answer

Increase tubal motility

Answer

Inhibit implantation of the fertilized egg

Answer

Inhibit ovulation

Answer

Induce biochemical changes in the endometrium

Question 3

A depot contraceptive, DMPA, is to be given every:

Accepted Answer

3 months

Answer

1 month

Answer

2 months

Answer

6 months

Question 4

Combined oral pills reduce the risk of?

Accepted Answer

Ovarian cancer

Answer

Breast cancer

Answer

Cervical cancer

Answer

Vaginal cancer

Question 5

Best long-acting reversible contraception (LARC) that can be inserted immediately postpartum in a lactating mother is:

Accepted Answer

Post Partum IUCD

Answer

Depot provera

Answer

Combined oral contraceptive pills (OCPs)

Answer

Calendar method

Question 6

Spermicidal jelly acts through what mechanism?

Accepted Answer

Lysis of sperm cell membrane

Answer

Acrosomal enzyme activity

Answer

Alteration of cervical mucus

Answer

Inhibition of glucose uptake by sperm

Question 7

What is the hormonal contraceptive of choice in a lactating woman?

Accepted Answer

Progestin-only pill

Answer

Combined oral contraceptive

Answer

Centchroman

Answer

Multiphasic oral contraceptive

Question 8

Which of the following is not typically used as an emergency contraceptive?

Accepted Answer

Estrogen

Answer

Combined oral pills

Answer

Levonorgestrel

Answer

Ulipristal acetate

Question 9

Which of the following tubal sterilization procedures is considered the least effective?

Accepted Answer

Hysteroscopic occlusion

Answer

Laparoscopic Yoon's ring method

Answer

Pomeroy's method

Answer

Vaginal fimbriectomy

Question 10

In the context of tubal ligation, what is the failure rate of Pomeroy's technique?

Accepted Answer

0.5-1%

Answer

0.1-0.5%

Answer

1-2%

Answer

5-10%

Contraception and Family Planning — MCQs

Contraception and Family Planning — MCQs

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