Rheumatology and Immunology — MCQs

A 30-year-old male presented with painful, deep recurrent oral aphthous ulcers. The ulcers had a yellowish necrotic base and appeared in crops. Painful genital ulcers and skin lesions were also seen. A test was performed wherein normal saline was injected intradermally. Bilateral panuveitis was noted on ophthalmoscopic examination. The patient also complained of arthralgia in bilateral knee joints. Lab findings revealed leukocytosis, raised ESR, and raised CRP. Which of the following antibodies can be seen in this condition?

A patient presents with severe pain and swelling in the great toe. Which of the following statements regarding gout are true?

A 60-year-old female complains of dry mouth and a gritty sensation in her eyes. She states it is sometimes difficult to speak for more than a few minutes. There is no history of diabetes mellitus or neurologic disease. The patient is on no medications. On exam, the buccal mucosa appears dry and the salivary glands are enlarged bilaterally. What is the next step in evaluation?

Hormonal abnormalities in men and post-menopausal women suffering from rheumatoid arthritis include the following, except?

Which of the following is NOT a risk factor associated with the development of gout?

A 40-year-old woman presents with a several-year history of widespread body pain and stiffness, predominantly affecting her shoulders, upper back, hips, thighs, and knees. She also reports significant fatigue, requiring up to 14 hours of low-quality sleep daily, and cognitive difficulties described as feeling "not all there mentally". Her vital signs are stable. Physical examination reveals pain on palpation of the deltoids, trapezius, latissimus dorsi, and quadriceps muscles. She has no joint deformities, swelling, or redness. Which of the following is the most likely diagnosis?

All are included in the criteria for diagnosis of systemic lupus erythematosus, except?

Which condition has a >90% association with HLA-B27?

All of the following are extraglandular manifestations of primary Sjögren's syndrome except?

A 19-year-old man with a history of recent-onset asthma presents with chest pain, intermittent claudication, and respiratory distress that is unresponsive to bronchodilators and antibiotics. Physical examination reveals mild hypertension (blood pressure = 150/100 mm Hg), bilateral wheezing, and numerous purpuric skin lesions on the feet. Laboratory studies demonstrate that leukocytes are increased to 14,000/mL with increased eosinophils and platelets are increased to 450,000/mL. BUN is elevated to 30 mg/dL, and serum creatinine is elevated to 3.5 mg/dL. The serum antineutrophil cytoplasmic antibody test is positive. Urinalysis discloses 3+ proteinuria and RBCs. A renal biopsy demonstrates vasculitis of medium-sized arteries, accompanied by eosinophilia. Which of the following is the most likely diagnosis?