Rheumatology and Immunology — MCQs

The most common pulmonary manifestation of Systemic Lupus Erythematosus (SLE) is:

A 38-year-old woman has had malaise and arthralgias for the past 14 months. On physical examination, she has scleral icterus and 1- to 3-cm areas of reddish-purple discoloration on her skin. Several of these areas show focal ulceration. Laboratory findings show total protein, 7.1 g/dL; albumin, 3.3 g/dL; AST, 127 U/L; ALT, 145 U/L; alkaline phosphatase, 80 U/L; total bilirubin, 4 mg/dL; and direct bilirubin, 3.1 mg/dL. Serologic test results are positive for anti-HCV and negative for anti-HBs and IgM anti-HAV. Urinalysis shows 4+ proteinuria and 1+ hematuria. CT scan of the abdomen shows a small amount of ascites, mild hepatomegaly, and no splenomegaly or lymphadenopathy. A biopsy specimen of an ulcerated skin lesion shows leukocytoclastic vasculitis involving the upper dermis. What is the most likely diagnosis?

A 65-year-old male develops sudden onset of severe knee pain, redness, swelling, and tenderness. He has a history of diabetes mellitus and cardiomyopathy. An X-ray of the knee shows linear calcification. Which of the following investigations is best for making a definitive diagnosis?

Which of the following is NOT a feature of secondary Sjögren's syndrome?

A 22-year-old male presents with complaints of dull lower back pain and morning stiffness. The pain was initially episodic but has now become persistent and bilateral. On physical examination, there is tenderness over the costosternal junctions, spinous processes of the vertebrae, and the iliac crests. Which of the following tests would be most likely to be helpful in establishing a diagnosis of ankylosing spondylitis?

A 23-year-old man complains of stiffness and pain in his lower back that causes him to awaken at night. He first noticed morning stiffness in his lower back during his college years. He also describes occasional pain in his right eye and sensitivity to light. An X-ray of the sacroiliac region shows fusion of the small joint spaces in the posterior spine and ossification of the intervertebral discs. Serologic tests for rheumatoid factor and antinuclear antibodies are negative. Which of the following human leukocyte antigen (HLA) haplotypes is this patient most likely to express?

What is the treatment of choice in Wegener's granulomatosis?

A patient presents with respiratory symptoms including cough and hemoptysis, along with glomerulonephritis. Serum C-ANCA levels were found to be elevated. What is the most likely diagnosis?

A 55-year-old patient presented with unilateral blindness, unilateral headache lasting for 2 months, and shows increased ESR. What is the most likely diagnosis?

What is not true about pseudogout?