Cardiology Practice Questions

Q: What is the preferred analgesic for pain associated with ST-elevation myocardial infarction (STEMI)?

Morphine. **Explanation:** **Morphine** is the preferred analgesic for pain management in ST-elevation myocardial infarction (STEMI) because it provides more than just potent analgesia. Its benefits in STEMI are twofold: 1. **Hemodynamic Effects:** Morphine acts as a **venodilator**, which reduces venous return (preload) and decreases the workload of the heart (myocardial oxygen demand). It also causes mild arterial vasodilation, reducing afterload. 2. **Anxiolytic Effect:** By relieving intense pain and anxiety, it reduces sympathetic nervous system activation, further lowering heart rate and blood pressure. **Why other options are incorrect:** * **Diclofenac (NSAIDs):** These are generally **contraindicated** in the acute phase of MI. NSAIDs (except Aspirin) increase the risk of myocardial rupture, impair infarct healing, and are associated with an increased risk of recurrent MI and heart failure due to pro-thrombotic effects. * **Paracetamol:** While safe, it lacks the potent analgesic and hemodynamic benefits (preload reduction) required to manage the severe ischemic pain of STEMI. * **Dicyclomine:** This is an anticholinergic/antispasmodic used for GI smooth muscle cramps; it has no role in cardiac pain. **High-Yield Clinical Pearls for NEET-PG:** * **Route:** Morphine should be given **Intravenously (IV)**. Intramuscular (IM) injections should be avoided in MI as they can interfere with CK-MB/Troponin levels and cause hematomas during thrombolysis. * **Caution:** Morphine can slow the absorption of oral antiplatelets (like Clopidogrel/Ticagrelor) due to delayed gastric emptying. * **Alternative:** If Morphine is unavailable or contraindicated (e.g., allergy), **Fentanyl** is the preferred alternative. * **Side Effect:** If Morphine causes excessive bradycardia or hypotension, **Atropine** is the antidote of choice.

Q: The following ECG represents?

P mitrale. ***P mitrale*** - Characterized by **broad, notched or bifid P waves** (>0.12 seconds) in lead II, indicating **left atrial enlargement**. - The **bifid appearance** results from delayed activation of the enlarged left atrium, creating the characteristic "M-shaped" P wave. *Rabbit ear pattern* - This refers to the **RSR' pattern** seen in **right bundle branch block (RBBB)** in leads V1-V2. - It involves **QRS complexes**, not P waves, and appears as two distinct peaks resembling rabbit ears. *Delta wave* - A **slurred upstroke** of the QRS complex seen in **Wolff-Parkinson-White (WPW) syndrome**. - Results from **pre-excitation** via an accessory pathway, causing early ventricular depolarization, not P wave abnormalities. *P pulmonale* - Indicates **right atrial enlargement** with **tall, peaked P waves** (>2.5 mm) in leads II, III, and aVF. - Associated with conditions like **COPD** and **pulmonary hypertension**, appearing narrow and pointed rather than broad and notched.

Q: Comment on the diagnosis from the ECG shown below?

RCA occlusion by thrombus. ***RCA occlusion by thrombus*** - **ST elevation** in **inferior leads (II, III, aVF)** is the classic ECG pattern for **right coronary artery (RCA)** occlusion. - The RCA typically supplies the **inferior wall** of the left ventricle and often the **posterior wall**, making this the most likely culprit vessel. *LAD occlusion by thrombus* - LAD occlusion would show **ST elevation** in **anterior leads (V1-V6)** and possibly **lead I and aVL**. - This pattern represents **anterior wall MI**, not the inferior wall changes seen in this ECG. *LCX occlusion by thrombus* - LCX occlusion typically causes **ST elevation** in **lateral leads (I, aVL, V5-V6)** or **posterior changes**. - May show **reciprocal ST depression** in anterior leads rather than the inferior lead changes observed. *Infarct* - While technically correct that an infarct is occurring, this option lacks **anatomical specificity**. - Fails to identify the **culprit vessel** or **location of infarct**, which is crucial for **treatment planning** and **prognosis**.

Q: Recurrent ischemic events following thrombosis have been pathophysiologically linked to which of the following?

Lipoprotein A. **Explanation:** **Lipoprotein (a) [Lp(a)]** is the correct answer because it possesses a unique structural homology with **plasminogen** [3]. Lp(a) consists of an LDL-like particle bound to apolipoprotein(a) [3]. Due to its similarity to plasminogen, it competitively inhibits the binding of plasminogen to fibrin and endothelial cell receptors [2][3]. This inhibition impairs fibrinolysis (the breakdown of clots), leading to a pro-thrombotic state [3]. Consequently, patients with elevated Lp(a) are at a significantly higher risk for recurrent ischemic events and "rebound" thrombosis following an initial vascular insult [3]. **Analysis of Incorrect Options:** * **Antibodies to thrombolytic agents:** While antibodies (e.g., anti-streptokinase) can neutralize the efficacy of specific drugs, they do not represent the primary pathophysiological mechanism for generalized recurrent ischemic events across the population [1]. * **Fibrinopeptide A:** This is a marker of active thrombin generation and fibrin formation. While it indicates an ongoing clotting process, it is a *product* of thrombosis rather than the underlying structural driver of recurrence. * **Triglycerides:** While hypertriglyceridemia is a risk factor for atherosclerosis, it does not have the direct anti-fibrinolytic properties that link Lp(a) specifically to recurrent thrombotic events. **Clinical Pearls for NEET-PG:** * **Lp(a) Level:** Levels are genetically determined and remain relatively constant throughout life; they are not significantly affected by diet or statins. * **Niacin and PCSK9 inhibitors** are known to lower Lp(a) levels, though clinical outcomes are still being studied. * **High-Yield Association:** Elevated Lp(a) is an independent risk factor for premature coronary artery disease (CAD) and calcific aortic stenosis [3].

Q: Paradoxical splitting of the second heart sound is heard in which of the following conditions?

Left bundle branch block (LBBB). The second heart sound (S2) consists of two components: **A2 (Aortic)** and **P2 (Pulmonary)**. Normally, A2 precedes P2, and the gap increases during inspiration (Physiological Splitting) [1]. **Paradoxical (Reversed) Splitting** occurs when A2 is significantly delayed, causing it to occur *after* P2. **Why LBBB is the Correct Answer:** In **Left Bundle Branch Block (LBBB)**, there is delayed depolarization of the left ventricle. This results in delayed closure of the aortic valve (A2). Consequently, P2 occurs before A2. During inspiration, the normal delay of P2 moves it closer to the delayed A2, narrowing the split. During expiration, P2 occurs earlier, widening the gap between P2 and A2. This "reverse" behavior compared to normal physiology defines paradoxical splitting. **Analysis of Incorrect Options:** * **RBBB (Option A):** Causes delayed right ventricular contraction, further delaying P2. This leads to **Wide Physiological Splitting** (A2 and P2 are far apart, widening further on inspiration). * **ASD (Option B):** Characterized by **Fixed Splitting**. The constant volume overload of the right heart keeps the P2 delay constant, regardless of the respiratory cycle. * **VSD (Option C):** Typically causes **Wide Physiological Splitting** due to increased right-sided volume and delayed P2, or it may be associated with a loud single S2 if pulmonary hypertension develops (Eisenmenger syndrome). **NEET-PG High-Yield Pearls:** * **Paradoxical Splitting Causes:** LBBB, Aortic Stenosis (severe), HOCM, and Patent Ductus Aueriosus (PDA). * **Fixed Splitting:** Pathognomonic for Atrial Septal Defect (ASD). * **Wide Splitting:** RBBB, Pulmonary Stenosis, and Mitral Regurgitation (due to early A2). * **Mnemonic for Paradoxical Split:** "The **L**eft side is **L**ate" (**L**BBB, **A**ortic **S**tenosis).

Question 1

A patient with an atrial septal defect (ASD) presents with a murmur similar to mitral regurgitation and left axis deviation of 40 degrees. What is the likely diagnosis?

Accepted Answer

Floppy mitral valve

Answer

Transposition of the great arteries (TGA)

Answer

Ostium secundum

Answer

Ostium primum

Question 2

What is Wenckebach phenomenon?

Accepted Answer

Progressive lengthening of the PR interval until a QRS complex is dropped

Answer

Slurred QRS complex

Answer

Irregular heart rate and premature ventricular beats

Answer

Shortened ST intervals

Question 3

What is the preferred analgesic for pain associated with ST-elevation myocardial infarction (STEMI)?

Accepted Answer

Morphine

Answer

Diclofenac

Answer

Paracetamol

Answer

Dicyclomine

Question 4

All of the following are usual features of left atrial myxoma, except?

Accepted Answer

Markedly enlarged left atrium

Answer

Raised ESR

Answer

Pyrexia

Answer

Systemic embolism

Question 5

The following ECG represents?

Accepted Answer

P mitrale

Answer

Rabbit ear pattern

Answer

Delta wave

Answer

P pulmonale

Question 6

Comment on the diagnosis from the ECG shown below?

Accepted Answer

RCA occlusion by thrombus

Answer

LAD occlusion by thrombus

Answer

LCX occlusion by thrombus

Answer

Infarct

Question 7

A 70-year-old man presents with dyspnea, orthopnea, and paroxysmal nocturnal dyspnea. His past medical history includes hypertension, type 2 diabetes, chronic kidney disease, and hypothyroidism. His medications include furosemide, enalapril, atorvastatin, metformin, and insulin. Physical examination reveals generalized cardiomegaly, and pulmonary and systemic venous hypertension. The ECG is shown in Figure below. What is the cardiac rhythm seen on the ECG?

Accepted Answer

Atrial flutter with 2:1 AV conduction

Answer

Ectopic atrial tachycardia

Answer

Sinus tachycardia

Answer

Supraventricular tachycardia

Question 8

Pulsus paradoxus is seen in which of the following conditions?

Accepted Answer

Emphysema/Asthma

Answer

Shock

Answer

Elderly

Answer

High output state

Question 9

Recurrent ischemic events following thrombosis have been pathophysiologically linked to which of the following?

Accepted Answer

Lipoprotein A

Answer

Antibodies to thrombolytic agents

Answer

Fibrinopeptide A

Answer

Triglycerides

Question 10

Paradoxical splitting of the second heart sound is heard in which of the following conditions?

Accepted Answer

Left bundle branch block (LBBB)

Answer

Right bundle branch block (RBBB)

Answer

Atrial septal defect (ASD)

Answer

Ventricular septal defect (VSD)

Cardiology — MCQs

Cardiology — MCQs

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