Cardiology Practice Questions

Q: High-output cardiac failure is seen in:

Thyrotoxicosis (Hyperthyroidism). ***Thyrotoxicosis (Hyperthyroidism)*** - High levels of thyroid hormones increase **basal metabolic rate** and cardiac output, leading to a state where the heart struggles to meet the body's excessive demands despite a normal or even elevated cardiac output. - This chronic state of increased cardiac workload can eventually lead to cardiac enlargement and **heart failure** despite good systolic function. *Heart failure with preserved ejection fraction (HFpEF)* - HFpEF is characterized by **diastolic dysfunction**, where the heart's pumping ability is normal but its relaxation and filling are impaired [1]. - While it represents a type of heart failure, it's typically understood as a **low-output state** or normal-output state relative to demand, not a high-output state caused by increased metabolic needs [2]. *Cor pulmonale (Right heart failure due to pulmonary hypertension)* - Cor pulmonale is **right ventricular failure** resulting from pulmonary hypertension, where the right side of the heart struggles to pump against increased resistance in the pulmonary circulation. - This condition is characterized by **elevated pulmonary vascular resistance** and often reduced cardiac output, not an intrinsic high-output state. *Aortic stenosis (Obstruction to left ventricular outflow)* - Aortic stenosis causes an **obstruction to blood flow** from the left ventricle, leading to increased pressure load on the left ventricle and eventual concentric hypertrophy. - This condition typically results in a **reduced or normal cardiac output** because of the outflow obstruction and is not considered a high-output state.

Q: What is the commonest site affected by thromboangiitis obliterans?

Digital arteries. ***Digital arteries*** - Thromboangiitis obliterans, also known as **Buerger's disease**, primarily affects the **small and medium-sized arteries and veins** of the upper and lower extremities. - The **digital arteries** (in fingers and toes) are the most commonly affected sites, leading to **ischemia**, pain, and eventually **gangrene** of the digits. *Femoral artery* - The **femoral artery** is a large artery in the thigh and is typically not the primary site of involvement in thromboangiitis obliterans. - Involvement of large arteries like the femoral artery is more characteristic of conditions such as **atherosclerosis**. *Popliteal artery* - The **popliteal artery** is located behind the knee and is also considered a medium-to-large artery. - While it can be affected in advanced or widespread cases of Buerger's disease, it is not the most common initial or predominant site of involvement. *Iliac artery* - The **iliac arteries** are large arteries supplying blood to the legs and pelvic organs. - These arteries are typically spared in thromboangiitis obliterans, which primarily targets distal, smaller vessels.

Q: What is the most common cause of sudden cardiac death in adults?

Arrhythmias. ***Arrhythmias*** - The most common cause of sudden cardiac death in adults is due to **ventricular fibrillation** or **ventricular tachycardia**, which are types of arrhythmias [2]. - These lethal arrhythmias are frequently triggered by underlying **coronary artery disease** [3]. *Cerebral haemorrhage* - While a serious and life-threatening condition, **cerebral haemorrhage** is not the most common cause of sudden cardiac death. - It primarily affects the brain and its immediate consequences are related to neurological function, although secondary cardiac issues can occur. *Ruptured aortic aneurysm* - A **ruptured aortic aneurysm** is a catastrophic event leading to massive internal bleeding and rapid death [1]. - However, its incidence is significantly lower than that of sudden cardiac death due to arrhythmias. *Cancer* - **Cancer** can lead to death but typically not as a sudden event in the way of sudden cardiac death. - Death from cancer is usually a more protracted process, often due to widespread metastatic disease or complications of treatment.

Q: The aortic component of the second heart sound is best heard at what location?

Right second intercostal space near the sternum. ***Right second intercostal space near the sternum*** - This location is the **aortic area**, where sounds originating from the **aortic valve** are best heard [1]. - The **aortic component of S2** (A2) is produced by the closure of the aortic valve. *Infraclavicular region* - This region is generally not used for auscultating specific heart valve sounds. - While some radiated sounds might be heard, it's not the primary location for the aortic component of S2. *Apex* - The apex is the best site for listening to sounds originating from the **mitral valve**, known as the **mitral area** [1]. - S1 is typically loudest at the apex, associated with mitral and tricuspid valve closure. *Left second intercostal space near the sternum* - This is the **pulmonic area**, which is where sounds from the **pulmonic valve** are best auscultated [1]. - The **pulmonic component of S2** (P2) is heard here, produced by the closure of the pulmonic valve [1].

Q: A man presents with chest pain, and his ECG shows ST segment depression in leads V1 to V4. Which of the following medications is contraindicated?

Thrombolytic. ***Thrombolytic*** - The ECG findings of **ST segment depression** in leads V1-V4 suggest **ischemia** or possibly a **non-ST elevation myocardial infarction (NSTEMI)** or **posterior MI**, but not an **ST elevation myocardial infarction (STEMI)**. - **Thrombolytics** are contraindicated in NSTEMI and are primarily reserved for STEMI when PCI is not available or delayed, due to the risk of bleeding without significant benefit [1]. *Beta blocker* - **Beta blockers** are often indicated in chest pain suspected to be cardiac in origin to reduce myocardial oxygen demand and improve outcomes, unless contraindicated by **bradycardia**, **hypotension**, or **heart failure** [1]. - They help decrease **heart rate** and **blood pressure**, lessening the workload on the heart [2]. *Morphine* - **Morphine** is used for significant pain relief in acute coronary syndromes, including NSTEMI, as it can reduce pain and anxiety [3]. - It works by reducing **preload** and **afterload** through systemic venodilation, which in turn reduces myocardial oxygen demand [3]. *Aspirin* - **Aspirin** is a cornerstone of therapy for acute coronary syndromes, including NSTEMI, due to its **antiplatelet effects** [4]. - It inhibits **platelet aggregation**, preventing further thrombus formation and reducing the risk of ischemic events [4].

Q: Coarctation of the aorta is associated with which of the following?

Bicuspid aortic valve. ***Bicuspid aortic valve*** - **Coarctation of the aorta** is strongly associated with a **bicuspid aortic valve**, which is a congenital abnormality where the aortic valve has only two cusps instead of the usual three [1]. - This association is clinically significant as patients with coarctation often require long-term follow-up for potential complications related to the bicuspid valve, such as **aortic stenosis** or **regurgitation** [1]. *TAPVC* - **Total anomalous pulmonary venous connection (TAPVC)** is a **cyanotic heart defect** where all four pulmonary veins drain abnormally into the systemic venous circulation. - It is not directly associated with coarctation of the aorta. *PDA* - A **patent ductus arteriosus (PDA)** is a common congenital heart defect, but it is not specifically or uniquely associated with coarctation of the aorta to the same extent as a bicuspid aortic valve. - While PDA can coexist with coarctation, it is not a direct or defining association. *Non-cyanotic heart defects* - While **coarctation of the aorta** is generally considered a non-cyanotic heart defect (unless severe or complicated by other defects), this option is too broad and does not identify the specific, most prominent associated anomaly. - There are numerous non-cyanotic heart defects, and this option does not provide the most relevant or specific association.

Q: Features of Torsade de pointes include which of the following?

Prolonged QTc interval. ***Prolonged QTc interval*** - **Torsade de pointes** (TdP) is a polymorphic ventricular tachycardia characterized by a twisting of the QRS complex around the isoelectric line [1]. - It is almost invariably associated with a **prolonged QTc interval**, which can be congenital or acquired due to drugs or electrolyte imbalances [1],[4]. *Wide QRS complex* - While TdP does involve **wide QRS complexes**, this is a general characteristic of most ventricular tachycardias and not specific enough to define Torsade de pointes [2]. - The distinctive feature of TdP is the **polymorphic nature** of the wide QRS complexes and their characteristic "twisting" pattern, which is rooted in the underlying repolarization abnormality [1]. *Short QRS complex* - A **short QRS complex** is characteristic of supraventricular arrhythmias and is not seen in ventricular tachycardias like Torsade de pointes [3]. - Ventricular activation originates in the ventricles, leading to a **wider QRS** due to slower, aberrant conduction [2]. *Short QTc interval* - A **short QTc interval** is linked to conditions like short QT syndrome, which can also cause arrhythmias but is not responsible for Torsade de pointes. - TdP exclusively occurs in the setting of **prolonged ventricular repolarization**, reflected by a long QTc [1],[4].

Q: What is the first-line treatment for rate control in a 60-year-old man with a history of atrial fibrillation who presents with palpitations and shortness of breath?

Beta-blockers. ***Beta-blockers*** - **Beta-blockers** are generally considered **first-line agents** for **rate control in atrial fibrillation** due to their effectiveness in reducing ventricular rate and improving symptoms [2]. - They work by blocking beta-adrenergic receptors, which **slows conduction** through the AV node [1]. *Amiodarone* - **Amiodarone** is primarily an **antiarrhythmic drug** used for rhythm control, not typically first-line for rate control. - It's reserved for cases where other rate control agents are ineffective or contraindicated, or in patients with **heart failure** where other rate controllers may be detrimental. *Digoxin* - **Digoxin** is a **less common first-line agent** for rate control in atrial fibrillation as its effects are often **suboptimal during exercise** and it has a narrow therapeutic index. - It is more effective for rate control at rest and may be considered in patients with **heart failure with reduced ejection fraction** or those who are sedentary. *Calcium channel blockers* - While **non-dihydropyridine calcium channel blockers** (e.g., verapamil, diltiazem) are effective for rate control in atrial fibrillation, **beta-blockers are often preferred as first-line** options unless contraindications exist. - They also **slow AV nodal conduction** but may have disadvantages such as **negative inotropic effects** that can be problematic in certain patients.

Question 1

High-output cardiac failure is seen in:

Accepted Answer

Thyrotoxicosis (Hyperthyroidism)

Answer

Heart failure with preserved ejection fraction (HFpEF)

Answer

Cor pulmonale (Right heart failure due to pulmonary hypertension)

Answer

Aortic stenosis (Obstruction to left ventricular outflow)

Question 2

What is the commonest site affected by thromboangiitis obliterans?

Accepted Answer

Digital arteries

Answer

Femoral artery

Answer

Popliteal artery

Answer

Iliac artery

Question 3

What is the most common cause of sudden cardiac death in adults?

Accepted Answer

Arrhythmias

Answer

Cerebral haemorrhage

Answer

Ruptured aortic aneurysm

Answer

Cancer

Question 4

The aortic component of the second heart sound is best heard at what location?

Accepted Answer

Right second intercostal space near the sternum

Answer

Infraclavicular region

Answer

Apex

Answer

Left second intercostal space near the sternum

Question 5

A man presents with chest pain, and his ECG shows ST segment depression in leads V1 to V4. Which of the following medications is contraindicated?

Accepted Answer

Thrombolytic

Answer

Morphine

Answer

Aspirin

Answer

Beta blocker

Question 6

Coarctation of the aorta is associated with which of the following?

Accepted Answer

Bicuspid aortic valve

Answer

TAPVC

Answer

PDA

Answer

Non-cyanotic heart defects

Question 7

Features of Torsade de pointes include which of the following?

Accepted Answer

Prolonged QTc interval

Answer

Wide QRS complex

Answer

Short QRS complex

Answer

Short QTc interval

Question 8

What is the first-line treatment for rate control in a 60-year-old man with a history of atrial fibrillation who presents with palpitations and shortness of breath?

Accepted Answer

Beta-blockers

Answer

Amiodarone

Answer

Digoxin

Answer

Calcium channel blockers

Cardiology — MCQs

Cardiology — MCQs

On this page

Practice by Chapter

Want unlimited practice?