Pigmentary Disorders Practice Questions

Q: False about melasma is?

More common in male. ***More common in male*** - **Melasma** is significantly **more common in females** (90%) than in males (10%), especially among women of childbearing age. - This strong female predominance is linked to **hormonal factors**, such as pregnancy and oral contraceptive use. - **This statement is FALSE**, making it the correct answer to this negation question. *Hydroquinone has role in the treatment* - **Hydroquinone** is a **first-line topical treatment** for melasma, working by inhibiting melanin synthesis. - It helps lighten hyperpigmented patches by reducing the activity of **tyrosinase**, a key enzyme in melanin production. *Commonly affects sun-exposed areas* - **Melasma** typically presents on **sun-exposed areas** of the face, particularly the cheeks, forehead, upper lip, and chin. - **UV exposure** is a major triggering and exacerbating factor, which is why sun protection is crucial in management. *Oral contraceptives can induce it* - **Oral contraceptive pills** are a well-known trigger for **melasma**, due to the hormonal changes they induce (estrogen and progesterone). - The elevated **hormone levels** stimulate melanocytes, leading to increased melanin production and hyperpigmentation.

Q: A patient presents with asymptomatic hyperpigmented macules showing accentuation under Wood's lamp. Most likely diagnosis:

Melasma. ***Melasma*** - Presents as **asymptomatic hyperpigmented macules** typically on sun-exposed areas like the face, and these lesions are known to show **accentuation under Wood's lamp** due to increased epidermal melanin deposition. - It is frequently associated with **hormonal changes**, such as pregnancy or oral contraceptive use, and sun exposure. *Tinea versicolor* - Caused by the yeast *Malassezia globosa*, presenting as **hypopigmented or hyperpigmented patches** with fine scale, often on the trunk. - Under Wood's lamp, tinea versicolor typically shows a characteristic **yellow-green fluorescence**, not accentuation of brown pigmentation. *Post-inflammatory hyperpigmentation* - Occurs as a result of **inflammation or injury to the skin**, leading to increased melanin production in the affected area. - While it can manifest as hyperpigmented macules, it generally does **not show significant accentuation under Wood's lamp** if the melanin is in the dermis, and its distribution follows sites of previous inflammation rather than sun-exposed patterns. *Café au lait macules* - These are **uniformly hyperpigmented, well-defined macules** that are typically present from birth or early childhood. - While they are hyperpigmented, they generally **do not show accentuation under Wood's lamp** as the melanin is usually distributed evenly within the epidermis and not subject to the same optical properties as melasma.

Q: All of the following are true about vitiligo EXCEPT:

Dermatomal distribution is common. ***Dermatomal distribution is common*** - Vitiligo is characterized by **patches of depigmentation** that result from the destruction of melanocytes. Its distribution is typically **generalized**, focal, segmental (unilateral and non-dermatomal), or localized, but not dermatomal. - A **dermatomal distribution** would imply a pattern corresponding to a single spinal nerve root, which is characteristic of conditions like **herpes zoster**, not vitiligo. *Koebner phenomenon may occur* - The **Koebner phenomenon**, or isomorphic response, is indeed observed in vitiligo, where new lesions appear at sites of trauma to previously unaffected skin. - This phenomenon is also seen in other dermatological conditions like **psoriasis** and **lichen planus**. *Associated with autoimmune thyroiditis* - Vitiligo is strongly associated with various **autoimmune diseases**, with **autoimmune thyroiditis** (Hashimoto's thyroiditis or Graves' disease) being one of the most common co-morbidities. - Other associated autoimmune conditions include **pernicious anemia**, **diabetes mellitus type 1**, and **Addison's disease**. *NBUVB is effective treatment* - **Narrowband ultraviolet B (NBUVB)** phototherapy is a highly effective treatment for vitiligo, particularly for generalized forms. - It works by stimulating residual melanocytes to proliferate and migrate, leading to **re-pigmentation** of the affected areas.

Q: A 45-year-old woman presents with progressive depigmented macules on her face and hands. Which autoimmune disease is most commonly associated with vitiligo?

Hashimoto's thyroiditis. ***Hashimoto's thyroiditis*** - **Hashimoto's thyroiditis** is the autoimmune disease most commonly associated with **vitiligo**, both conditions sharing a genetic predisposition and mechanisms involving the immune system attacking specific cells (melanocytes in vitiligo, thyroid cells in Hashimoto's). - The co-occurrence suggests a broader autoimmune diathesis, making thyroid function testing important in patients with vitiligo. *Addison's disease* - While **Addison's disease** (adrenal insufficiency) can be associated with vitiligo, it is less common than the association with thyroid autoimmune diseases. - Addison's disease involves autoimmune destruction of the adrenal glands, leading to symptoms like fatigue, weight loss, and hyperpigmentation (paradoxically, in some areas, or generalized), though vitiligo can also occur. *Graves' disease* - **Graves' disease** is an autoimmune hyperthyroid condition that can also be associated with vitiligo, but the prevalence of this association is lower compared to **Hashimoto's thyroiditis**. - Both conditions represent organ-specific autoimmune diseases, but Hashimoto's, an organ-specific autoimmune disease affecting the thyroid, has a stronger epidemiological link with vitiligo. *Systemic lupus erythematosus* - While **systemic lupus erythematosus (SLE)** is a systemic autoimmune disease that can affect various organs and present with diverse dermatological manifestations, including photosensitivity and discoid lupus, it is not primarily or most commonly associated with **vitiligo**. - SLE is characterized by autoantibodies against nuclear antigens, and its skin involvement typically presents as rashes or lesions, rather than generalized depigmentation.

Q: A 50-year-old woman presents with a well-demarcated depigmented patch on her hand. Which of the following conditions is most likely?

Vitiligo. ***Vitiligo*** - **Vitiligo** is characterized by the presence of **well-demarcated** patches of complete **depigmentation** due to the destruction of melanocytes. - The appearance of such a patch on the hand is a classic presentation of this autoimmune skin condition. *Melasma* - **Melasma** presents as **hyperpigmented** macules and patches, typically on sun-exposed areas like the face, not hypopigmented lesions. - It is associated with hormonal changes, such as pregnancy or oral contraceptive use. *Pityriasis alba* - **Pityriasis alba** causes **hypopigmented** (lighter, but not completely depigmented) patches with fine scale, often on the face and arms of children. - Unlike vitiligo, the lesions are not typically as starkly white and usually resolve spontaneously over time. *Addison's disease* - **Addison's disease** is characterized by **hyperpigmentation**, especially in areas of friction or sun exposure, due to increased ACTH and MSH. - While it can cause skin changes, it does not typically present with singular, well-demarcated depigmented patches like vitiligo.

Q: A 55-year-old man with a history of vitiligo presents with several new hypopigmented macules on his trunk and extremities. What is the most likely diagnosis?

Vitiligo. ***Vitiligo (Progressive Disease)*** - The patient has a **history of vitiligo**, and new **hypopigmented macules** are consistent with **disease progression**. - Vitiligo is an **autoimmune disorder** characterized by the destruction of **melanocytes**, leading to progressive depigmentation of the skin with characteristic **well-demarcated, chalk-white patches**. - In patients with established vitiligo, **new lesions typically represent extension of the same disease** rather than a new diagnosis, especially when presenting with similar morphology. *Pityriasis alba* - This condition typically presents as **faintly erythematous patches** that resolve to leave **hypopigmented areas**, often with fine scaling, and is more common in children. - It does not usually present with the **sharp, well-demarcated depigmentation** seen in vitiligo, and a history of vitiligo makes this diagnosis less likely. - The lesions are usually **ill-defined** and show **incomplete depigmentation**, unlike the complete depigmentation of vitiligo. *Tinea versicolor* - Caused by a **yeast infection (Malassezia species)**, it typically presents with **hypopigmented OR hyperpigmented patches** with fine scale, often on the trunk. - While it causes hypopigmentation, the patches are usually **superficial with fine scaling** and respond to antifungal treatment. - The patient's existing history of an autoimmune disease like vitiligo and the **well-demarcated nature** of the lesions point away from this fungal etiology. *Leprosy* - Leprosy can cause **hypopigmented patches**, but these lesions are typically associated with **diminished sensation** (anesthesia) and nerve involvement. - The absence of neurological symptoms and the presence of a prior vitiligo diagnosis make leprosy a less probable diagnosis in this context. - Leprosy patches show **loss of sensation, anhidrosis, and loss of hair** within the patch, which would be key differentiating features.

Q: A 25-year-old female presents with brown macular lesions on her face that appeared after sun exposure. What is the most likely diagnosis?

Chloasma. ***Chloasma*** - **Chloasma**, also known as **melasma**, presents as brown macular lesions (hyperpigmentation) on the face, often exacerbated by **sun exposure** and hormonal changes (e.g., pregnancy, oral contraceptives). - This condition is common in women and directly aligns with the patient's presentation of **facial brown macules** appearing after sun exposure. *Photodermatitis* - **Photodermatitis** is an inflammatory reaction of the skin caused by exposure to light, often manifesting as **redness, itching, and blistering**, not typically as brown macules. - It usually presents as an acute eczematous or bullous response, which is inconsistent with the patient's description of persistent brown lesions. *Systemic lupus erythematosus* - **Systemic lupus erythematosus (SLE)** is an autoimmune disease with diverse cutaneous manifestations, but a classic finding is the **malar rash** (butterfly rash), which is red and often affects the nose and cheeks, not brown macules. - Other skin manifestations of SLE include discoid lesions or photosensitivity with erythema and scaling, not the diffuse facial hyperpigmentation described. *Acne rosacea* - **Acne rosacea** is a chronic inflammatory skin condition characterized by **facial redness, papules, pustules**, and prominent blood vessels (telangiectasias), primarily affecting the central face. - While rosacea can be triggered by sun exposure, it presents with **erythema and inflammatory lesions**, not the brown macular hyperpigmentation seen in this patient.

Q: Identify the condition in the image

Vitiligo. ***Correct: Vitiligo*** - This image shows **patches of depigmented skin** (white areas) characteristic of vitiligo, often seen in a **segmental or generalized pattern**. - Vitiligo is an **autoimmune condition** where melanocytes are destroyed, leading to loss of skin color. - Patches typically have a **progressive course** and can appear at any age. *Incorrect: Leukoderma* - Leukoderma is a **general term** for any condition causing white patches on the skin due to reduced or lost pigmentation. - While vitiligo is a type of leukoderma, this answer is too broad and not the **most specific diagnosis** for the pattern shown. - In clinical practice, we diagnose the specific type (vitiligo) rather than using the generic term. *Incorrect: Piebaldism* - Piebaldism is a **rare genetic disorder** characterized by a **stable white forelock** (unpigmented hair) and often a congenital white patch on the forehead. - Unlike vitiligo, these patches are usually **present at birth** and do not progress. - The distribution pattern is typically **midline** with characteristic forehead involvement. *Incorrect: DLE* - DLE stands for **Discoid Lupus Erythematosus**, which is a chronic autoimmune condition affecting the skin. - It typically presents as **red, scaly, disk-shaped plaques** that can lead to scarring, atrophy, and permanent hair loss. - Would show **erythema, scaling, and scarring** rather than pure depigmentation as seen here.

Q: Which condition is characterized by the presence of hypopigmented macules?

Tuberous sclerosis. ***Tuberous sclerosis*** - **Hypopigmented macules**, often described as **ash-leaf spots**, are a classic cutaneous manifestation of tuberous sclerosis. - These spots are usually present from birth or early infancy and are an important diagnostic criterion for the condition. *Addison's disease* - Characterized by **hyperpigmentation**, particularly in sun-exposed areas, skin folds, and mucous membranes, due to increased ACTH stimulating melanocytes. - It does not typically present with hypopigmented macules. *Porphyria* - Manifests with various skin findings, including **photosensitivity**, blistering, increased fragility, and hair growth, but not primary hypopigmented macules. - The skin changes are often related to the accumulation of porphyrins in the skin. *Cutaneous mastocytosis* - Characterized by accumulations of **mast cells** in the skin, leading to lesions that can include **urticaria pigmentosa** (reddish-brown macules or papules that urticate when rubbed). - It does not typically present with hypopigmented macules as a primary feature.

Question 1

False about melasma is?

Accepted Answer

More common in male

Answer

Hydroquinone has role in the treatment

Answer

Commonly affects sun-exposed areas

Answer

Oral contraceptives can induce it

Question 2

A patient presents with asymptomatic hyperpigmented macules showing accentuation under Wood's lamp. Most likely diagnosis:

Accepted Answer

Melasma

Answer

Tinea versicolor

Answer

Post-inflammatory hyperpigmentation

Answer

Café au lait macules

Question 3

All of the following are true about vitiligo EXCEPT:

Accepted Answer

Dermatomal distribution is common

Answer

Koebner phenomenon may occur

Answer

Associated with autoimmune thyroiditis

Answer

NBUVB is effective treatment

Question 4

A 45-year-old woman presents with progressive depigmented macules on her face and hands. Which autoimmune disease is most commonly associated with vitiligo?

Accepted Answer

Hashimoto's thyroiditis

Answer

Addison's disease

Answer

Graves' disease

Answer

Systemic lupus erythematosus

Question 5

A patient presents with multiple hyperpigmented macules on the trunk and extremities. A biopsy shows increased melanin in the basal layer with no increase in melanocytes. What is the most likely diagnosis?

Accepted Answer

Post-inflammatory hyperpigmentation

Answer

Lentigo

Answer

Melasma

Answer

Addison's disease

Question 6

A 50-year-old woman presents with a well-demarcated depigmented patch on her hand. Which of the following conditions is most likely?

Accepted Answer

Vitiligo

Answer

Melasma

Answer

Pityriasis alba

Answer

Addison's disease

Question 7

A 55-year-old man with a history of vitiligo presents with several new hypopigmented macules on his trunk and extremities. What is the most likely diagnosis?

Accepted Answer

Vitiligo

Answer

Pityriasis alba

Answer

Tinea versicolor

Answer

Leprosy

Question 8

A 25-year-old female presents with brown macular lesions on her face that appeared after sun exposure. What is the most likely diagnosis?

Accepted Answer

Chloasma

Answer

Photodermatitis

Answer

Systemic lupus erythematosus

Answer

Acne rosacea

Question 9

Identify the condition in the image

Accepted Answer

Vitiligo

Answer

Leukoderma

Answer

Piebaldism

Answer

DLE

Question 10

Which condition is characterized by the presence of hypopigmented macules?

Accepted Answer

Tuberous sclerosis

Answer

Addison's disease

Answer

Porphyria

Answer

Cutaneous mastocytosis

Pigmentary Disorders — MCQs

Pigmentary Disorders — MCQs

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