Drug Metabolism Practice Questions

Question 1

What is the mechanism of metabolism for alcohol, aspirin, and phenytoin at high doses?

Accepted Answer

Zero order kinetics

Answer

First pass kinetics

Answer

First order kinetics

Answer

Second order kinetics

Question 2

A factor that is likely to increase the duration of action of a drug that is partially metabolized by CYP3A4 in the liver is:

Accepted Answer

Chronic administration of cimetidine with the drug

Answer

Chronic administration of phenobarbital with the drug

Answer

Displacement from tissue binding sites by another drug

Answer

Chronic administration of rifampicin

Question 3

Phase 1 biotransformation includes

Accepted Answer

Reduction

Answer

Methylation

Answer

Acetylation

Answer

Sulfate conjugation

Question 4

Glucuronide reaction is seen in

Accepted Answer

Phase 2

Answer

NADPH-dependent reaction

Answer

Phase 1

Answer

Non enzymatic reaction

Question 5

A patient is on warfarin therapy. All of the following drugs increase the risk of bleeding with warfarin except?

Accepted Answer

Carbamazepine

Answer

Isoniazid

Answer

Amiodarone

Answer

Cimetidine

Question 6

Bile salts undergo conjugation for enhanced solubility:

Accepted Answer

After conjugation with taurine and glycine

Answer

After conjugation with derived proteins

Answer

After conjugation with lysine

Answer

After conjugation with betaglucuronic acid

Question 7

All of the following are true about glutathione, except:

Accepted Answer

It converts hemoglobin to methemoglobin

Answer

It is co-factor of various enzymes

Answer

It is a tripeptide

Answer

It conjugates xenobiotics

Question 8

Which of the following statements is FALSE regarding Cytochrome P 450?

Accepted Answer

They are non-heme proteins.

Answer

They are essential for the production of cholesterols, steroids, prostacyclins, and thromboxane A2.

Answer

They absorb light with 450 nm wavelength.

Answer

They occur predominantly in the liver.

Question 9

Methanol toxicity causes blindness due to the formation of:

Accepted Answer

Formic acid

Answer

Formaldehyde

Answer

Lactic acid

Answer

Pyruvic acid

Question 10

Alcohol is metabolized by all the following pathways except?

Accepted Answer

Aldehyde dehydrogenase

Answer

Alcohol dehydrogenase

Answer

MEOS (Microsomal Ethanol Oxidizing System)

Answer

Catalase

Drug Metabolism — MCQs

Drug Metabolism — MCQs

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