Pain Physiology and Pathways — MCQs

A 10-year-old boy cuts his finger with a pocketknife and immediately applies pressure to the damaged area with his other hand to partially alleviate the pain. Inhibition of pain signals by tactile stimulation of the skin is mediated by which type of afferent neurons from mechanoreceptors?

Which substance enhances the sensitivity of pain receptors but does not directly excite them?

Stimulation of which of the following areas of brain is experimentally used to control intractable pain -

Pain and temperature are carried by:

Activation of which of the following fibers results in first pain, which helps to localize the site and intensity of the noxious stimulus?

A female developed pain and a sensation like insects crawling on her legs at night which is relieved by shaking her legs. Which of the following is the drug of choice for this condition?

Primary Dysmenorrhoea can be treated by which of the following? 1. Antiprostaglandin 2. Cyclic combined estrogen and progesterone preparations 3. Pre-sacral neurectomy 4. Uterine curettage

Which of the following anaesthetic agent lacks analgesic effect? A) N2O B) Thiopentone C) Methohexitone D) Ketamine E) Fentanyl

A 62-year-old woman with advanced ovarian cancer has been on oral morphine 90 mg BD for 3 months. She now reports reduced pain relief despite increasing doses, but experiences severe pain at specific sites of bone metastases. What is the best management strategy?

A 70-year-old man with advanced pancreatic cancer on sustained-release morphine 60 mg BD develops breakthrough pain 3-4 times daily. His pain is otherwise well controlled. What should be the dose of immediate-release morphine for breakthrough pain?