A 63-year-old man with high blood pressure, dyslipidemia, and diabetes presents to the clinic for routine follow-up. He has no current complaints and has been compliant with his chronic medications. His blood pressure is 132/87 mm Hg and his pulse is 75/min and regular. On physical examination, you notice that he has xanthelasmas on both of his eyelids. He currently uses a statin to lower his LDL but has not reached the LDL goal you have set for him. You would like to add an additional medication for LDL control. Of the following, which statement regarding fibrates is true?

Fibrates can potentiate the risk of myositis when given with statins

Fibrates inhibit the rate-limiting step in cholesterol synthesis

Fibrates can cause significant skin flushing and pruritus

Fibrates can increase the risk of cataracts

The primary effect of fibrates is to lower LDL

A 45-year-old man presents to the emergency department with difficulties swallowing food. He states that he experiences pain when he attempts to swallow his medications or when he drinks water. He reveals that he was diagnosed with HIV infection five years ago. He asserts that he has been taking his antiretroviral regimen, including emtricitabine, rilpivirine, and tenofovir. His temperature is 98°F (37°C), blood pressure is 100/60 mmHg, pulse is 90/min, respirations are 22/min, and oxygen saturation is 99% on room air. His physical exam is notable for a clear oropharynx, no lymphadenopathy, and a normal cardiac and pulmonary exam. No rashes are noted throughout his body. His laboratory results are displayed below: Hemoglobin: 12 g/dL Hematocrit: 37 % Leukocyte count: 8,000/mm^3 with normal differential Platelet count: 160,000/mm^3 Serum: Na+: 138 mEq/L Cl-: 108 mEq/L K+: 3.5 mEq/L HCO3-: 26 mEq/L BUN: 35 mg/dL Glucose: 108 mg/dL Creatinine: 1.1 mg/dL CD4+ count: 90/mm^3 HIV viral load: 59,000 copies/mL What is the best next step in management?

Esophageal endoscopy and biopsy

Inhibition of squalene epoxidase

Shampoo containing zinc pyrithione

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Drug interactions with antifungals: High-Yield Pharmacology Notes | Oncourse