2,3-DPG effects on oxygen affinity — Flashcards

Flashcard 1: How do levels of 2,3-BPG change at high altitudes? _____

Answer: Increased

Flashcard 2: 2,3-BPG increases under _____ conditions (e.g. high altitude)

Answer: hypoxic

Flashcard 3: The _____ of the oxygen-Hb dissociation curve is the Po2 at which hemoglobin is 50% saturated

Answer: P50

Flashcard 4: Carboxyhemoglobin heme groups not bound by CO have a(n) _____ affinity for O2

Answer: increased

Flashcard 5: What is the secondary regulator of cerebral perfusion?

Answer: PO2 - only takes effect during severe hypoxia

Flashcard 6: What is the primary regulator of cerebral perfusion?

Answer: PCO2

Flashcard 7: How long can the brain withstand hypoxia before sustaining irreversible damage?

Answer: 5 minutes

Flashcard 8: COPD, cyanotic congenital heart disease, obstructive sleep apnea, and high altitude cause _____ polycythemia

Answer: physiologic secondary

Extra:  * due to chronic hypoxia Watch Polycythemia [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-myeloid-lymphoid/videos/medical-pathophysiology-myeloid-and-lymphoid-myeloid-disorders-polycythemia?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki 

Flashcard 9: Which zone of the lung has the highest Pao2? _____

Answer: Zone 1

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/blood?index=14] https://onlinemeded.org?ref=anki 

Flashcard 10: In the _____, HCO3- enters the red blood cells in exchange for Cl-

Answer: lungs

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/pulmonology/videos/blood?index=12] https://onlinemeded.org?ref=anki