Posterior pituitary hormones — Flashcards

Flashcard 1: Desmopressin may be used to treat night _____

Answer: enuresis (bed wetting)

Flashcard 2: What is the most common side effect of SNRIs? _____

Answer: Hypertension

Flashcard 3: Treatment for central diabetes insipidus includes hydration and _____, which is an ADH analog

Answer: desmopressin

Flashcard 4: What is a serious complication of vaptans (e.g. tolvaptan, conivaptan) that may occur if SIADH-induced hyponatremia is corrected too quickly? _____

Answer: Central pontine myelinolysis (osmotic demyelination syndrome)

Flashcard 5: In addition to central diabetes insipidus, desmopressin (DDAVP) may be used to treat _____, which is associated with hemarthrosis and prolonged bleeding after minor procedures

Answer: hemophilia A

Flashcard 6: Clomiphene is an partial agonist at _____ receptors in the hypothalamus

Answer: estrogen

Flashcard 7: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 8: clompihene

Answer: SERM

Extra: infertility and PCOSpartial agonist at estrogen receptor, prevents feedback inhibitionhot flashes, ovarian enlargement, multiple pregnancy, visual disturbances

Flashcard 9: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 10: raloxifene

Answer: SERM

Extra: osteoporosis (reduces bone resorption)agonist at estrogen receptor; specific to bone