Insulin preparations and kinetics — Flashcards

Flashcard 1: A metabolic adverse effect of mecasermin, a recombinant IGF-1, is _____

Answer: hypoglycemia

Flashcard 2: Protease inhibitors can result in hyperglycemia due to _____ resistance

Answer: insulin

Flashcard 3: Insulin Detemir and Glargine are characterized by _____ action and duration

Answer: long

Flashcard 4: GLP-1 analogs cause increased _____ release and satiety

Answer: insulin

Flashcard 5: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 6: clompihene

Answer: SERM

Extra: infertility and PCOSpartial agonist at estrogen receptor, prevents feedback inhibitionhot flashes, ovarian enlargement, multiple pregnancy, visual disturbances

Flashcard 7: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 8: raloxifene

Answer: SERM

Extra: osteoporosis (reduces bone resorption)agonist at estrogen receptor; specific to bone

Flashcard 9: progestins

Answer:

Extra: contraception, endometrial cancer, abnormal uterine bleedingbinds progesterone receptor; reduces proliferation of endometrium, thickens cervical mucus

Flashcard 10: mifepristone (RU-486)

Answer:

Extra: abortion; administered with misoprostolcompetitive inhibitor at progesterone receptorheavy bleeding, abdominal pain