Glutamate antagonist antiepileptics — Flashcards

Flashcard 1: Amphetamines exert their effects by _____ catecholamines (NE, dopamine) into the synapse

Answer: displacing

Flashcard 2: Which atypical antidepressant may cause seizures in anorexic/bulimic patients? _____

Answer: Buproprion

Flashcard 3: Valproic acid can cause neurologic side effects, such as _____

Answer: tremor

Flashcard 4: Vigabatrin is an anti-epileptic that exerts its effects via inhibition of the enzyme _____

Answer: GABA transaminase

Flashcard 5: What type(s) of seizures (partial, tonic-clonic, or absence) may be treated with valproic acid? _____

Answer: All three (partial, tonic-clonic, absence)

Flashcard 6: Topiramate increases GABA action via allosterically binding to the _____ receptor

Answer: GABAA

Flashcard 7: carbamazepine

Answer: neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

Flashcard 8: phenytoin

Answer: fetal hydantoin syndrome

Flashcard 9: valproate

Answer: neural tube defects (inhibition of maternal folate absorption)

Flashcard 10: levodopa

Answer:

Extra: Parkinson's diseasedopamine precursor, crosses blood-brain barrier, converted to dopamine by dopa decarboxylaseGI distress, nausea, arrhythmias, dyskinesia (on dose), akinesia (between dose)