Autonomic drug interactions — Flashcards

Flashcard 1: Cholinomimetics _____ acetylcholine receptors are found in effector tissues (e.g. heart, smooth muscle, brain, glands)

Answer: Muscarinic (Muscarinic or Nicotinergic?)

Flashcard 2: What G-protein is the M2 muscarinic receptor coupled to? _____

Answer: Gi

Flashcard 3: In the presence of MAO inhibitors, tyramine enters the circulation and acts as a _____ agent

Answer: sympathomimetic

Flashcard 4: Organophosphate toxicity may be treated with _____, which regenerates AChE at muscarinic and nicotinic receptors if given early

Answer: pralidoxime

Flashcard 5: Phenylephrine causes _____ systolic pressure

Answer: increased

Flashcard 6: Epinephrine causes _____ diastolic pressure

Answer: decreased

Flashcard 7: Phenylephrine causes reflex _____ (HR)

Answer: bradycardia

Flashcard 8: Neuro/Psych _____ is an 1 and 2 antagonist that can be used to manage the hypertensive symptoms of tyramine toxicity

Answer: Phentolamine

Flashcard 9: Does atropine reverse the flaccid paralysis associated with cholinesterase inhibitor poisoning? _____

Answer: No, only effective at muscarinic receptors

Flashcard 10: terbutaline

Answer:

Extra: relaxation of premature uterine contractionsβ2 - agonist