Autonomic/CV Drugs — Flashcards

Flashcard 2661: Typical antipsychotics may cause symptoms of _____ excess (e.g. galactorrhea, amenorrhea, gynecomastia)

Answer: prolactin

Flashcard 2662: What high-yield sexual side effect is associated with **trazodone**?

Answer: Priapism

Extra: Trazodone is a SARI (Serotonin Antagonist and Reuptake Inhibitor) often used for insomnia. It is famously associated with priapism ('Trazo-bone') due to its α1-blocking effects. Notably, it lacks the standard sexual side effects (e.g., decreased libido, anorgasmia) associated with SSRIs.

Flashcard 2663: Sunitinib and sorafenib treat cancer due to VEGFR overexpression, such as _____ carcinoma

Answer: renal cell

Flashcard 2664: _____ are first line agents for treatment of acute gout, as they block prostaglandin synthesis at COX

Answer: NSAIDs (ie: indomethacin)

Flashcard 2665: _____ is used for prophylaxis and acute management of DVT

Answer: Unfractionated or LMW heparin

Flashcard 2666: Sildenafil causes cyanopia via inhibition of _____ in the retina.

Answer: PDE-6

Flashcard 2667: Which anti-epileptic is most associated with DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms)? _____

Answer: Phenytoin

Flashcard 2668: What drug class do eptifibatide and tirofiban belong to?_____

Answer: GPIIb/IIIa inhibitors

Flashcard 2669: Adenosine _____ conduction velocity through the AV node

Answer: decreases

Flashcard 2670: Is mannitol associated with hypernatremia or hyponatremia as a possible adverse effect? _____

Answer: Both

Extra: Mannitol can cause both: 1. **Hyponatremia**: Initially, mannitol expands the extracellular fluid volume by pulling water out of cells, resulting in dilutional hyponatremia. 2. **Hypernatremia**: Subsequently, it leads to osmotic diuresis. Since water is lost in excess of sodium (free water clearance), this can lead to dehydration and hypernatremia.