Autonomic/CV Drugs — Flashcards

Flashcard 2631: Alpha-receptor antagonists may cause _____ (BP) as an adverse effect.

Answer: Orthostatic hypotension

Extra: Alpha-1 receptor antagonists (e.g., prazosin, doxazosin, terazosin) inhibit vasoconstriction, leading to a drop in blood pressure upon standing. This is often referred to as the "first-dose phenomenon."

Flashcard 2632: Which osmotic diuretic may cause dehydration as a possible adverse effect? _____

Answer: Mannitol

Flashcard 2633: Phenobarbital is an _____ of CYP-450

Answer: inducer

Flashcard 2634: Does administering HCO3 for tricyclic antidepressant toxicity accelerate drug metabolism?_____

Answer: No - only overcomes Na channel-blocking activity

Flashcard 2635: Thiopental causes _____ cerebral blood flow

Answer: decreased

Flashcard 2636: Activation of beta-1 and beta-2 adrenergic receptors _____ lipolysis and release of fatty acids.

Answer: stimulates

Extra: Beta-receptors (β1, β2, β3) are Gs-coupled and stimulate lipolysis via the cAMP-PKA pathway, which activates hormone-sensitive lipase. Conversely, α2 receptors are Gi-coupled and inhibit lipolysis.

Flashcard 2637: One adverse effect associated with digoxin is _____ due to parasympathetic activity at AV node

Answer: heart block

Flashcard 2638: Triptans inhibit _____ nerve activation

Answer: trigeminal

Flashcard 2639: What is the most serious adverse effect associated with antipsychotics? _____

Answer: Neuroleptic malignant syndrome (NMS)

Flashcard 2640: First Aid Pharmacology: Endocrine_____ is a possible teratogenic complication of methimazole if given in the first trimester

Answer: Aplasia cutis