Autonomic/CV Drugs — Flashcards

Flashcard 2611: Unlike phenylephrine, norepinephrine causes increased _____ due to beta-1 activation which results in increased pulse pressure

Answer: cardiac contractility

Flashcard 2612: Activation of beta-1 and beta-2 adrenergic receptors _____ lipolysis and release of fatty acids.

Answer: stimulates

Extra: Beta-receptors (β1, β2, β3) are Gs-coupled and stimulate lipolysis via the cAMP-PKA pathway, which activates hormone-sensitive lipase. Conversely, α2 receptors are Gi-coupled and inhibit lipolysis.

Flashcard 2613: Dyslipidemia drugs _____ bind bile acids in the intestinal lumen, preventing absorption and recycling to the liver

Answer: Bile acid resins (e.g. cholestyramine)

Flashcard 2614: Which long-acting μ-opioid receptor agonist is used to attenuate opioid withdrawal symptoms? Bonus: It is also an antagonist at which receptor?

Answer: Methadone Bonus: NMDA receptor

Flashcard 2615: _____ is a thioamide that works by inhibiting Thyroid peroxidase ONLY

Answer: Methimazole

Flashcard 2616: One adverse effect associated with digoxin is _____ due to parasympathetic activity at AV node

Answer: heart block

Flashcard 2617: Adverse effects of clonidine include CNS and respiratory _____

Answer: depression

Flashcard 2618: benzodiazepines can be used in _____ (muscle relaxation, amnesia)

Answer: general anesthesia

Flashcard 2619: Alpha-receptor antagonists may cause _____ (BP) as an adverse effect.

Answer: Orthostatic hypotension

Extra: Alpha-1 receptor antagonists (e.g., prazosin, doxazosin, terazosin) inhibit vasoconstriction, leading to a drop in blood pressure upon standing. This is often referred to as the "first-dose phenomenon."

Flashcard 2620: NSAIDs can _____ blood pressure

Answer: increase