Autonomic/CV Drugs — Flashcards

Flashcard 2391: Irinotecan and topotecan can result in _____-suppression

Answer: myelo

Flashcard 2392: Cardiac glycosides (e.g. digoxin) exert their effects via inhibition of the _____ pump

Answer: Na+-K+ ATPase

Flashcard 2393: NSAIDs can cause _____ necrosis (kidney) as an adverse effect

Answer: renal papillary

Flashcard 2394: What drug intoxication presents as pupillary dilation, grandiosity, hypertension, and paranoia that lasts for multiple hours? _____

Answer: Amphetamines

Flashcard 2395: NSAIDs increase the risk of GI bleeding primarily through the inhibition of which enzyme?

Answer: COX-1

Extra: Inhibition of **COX-1** leads to: 1. Decreased **PGE2 and PGI2**: Reduces gastric mucosal protection (decreases mucus and bicarbonate secretion, decreases blood flow). 2. Decreased **TXA2**: Inhibits platelet aggregation, which increases the tendency to bleed from any mucosal damage.

Flashcard 2396: Alpha-glucosidase inhibitors (e.g. acarbose, miglitol) reduce the activity of alpha-glucosidases on the _____, thus delaying carbohydrate hydrolysis and absorption

Answer: intestinal brush border

Flashcard 2397: Because Sorafenib and Sunitinib target the Vascular Endothelial Growth Factor receptor, patients are at increased risk of _____

Answer: hemorrhage

Flashcard 2398: Local anesthetics are most effective in _____-firing neurons (speed)

Answer: rapidly

Flashcard 2399: What are the first-line pharmacologic treatments (2) for PTSD? _____

Answer: SSRIs or venlafaxine

Flashcard 2400: What adverse effects (2) are associated with fenoldopam? _____

Answer: Hypotension, Reflex Tachycardia