Cardiac glycosides — Flashcards

Flashcard 1: Cardiac glycosides (e.g. digoxin) exert their effects via inhibition of the _____ pump

Answer: Na+-K+ ATPase

Flashcard 2: Magnesium may be used as an antiarrhythmic to treat _____ toxicity

Answer: digoxin

Flashcard 3: What class of drugs directly inhibit the Na+-K+ ATPase pump?_____

Answer: Cardiac glycosides (e.g. digoxin)

Flashcard 4: One factor that predisposes to digoxin toxicity is _____ insufficiency, which decreases drug excretion

Answer: renal

Flashcard 5: Digoxin is useful in the treatment of _____ fibrillation (and flutter)

Answer: atrial

Flashcard 6: vardenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 7: sildenafil

Answer: PDE5 inhibitor

Extra: erectile dysfunctionpatients taking nitrates (lethal hypotension)inhbit phosphodiesterase 5, resulting in increased cGMP and smooth muscle relaxation in corpus cavernosumheadache, flushing, impaired blue-green color vision, hypotension, dyspepsia

Flashcard 8: aspirin

Answer:

Extra: increases permeability of the mitochondrial membrane (incomplete)inhibit oxidative phosphorylation

Flashcard 9: ouabain

Answer:

Extra: inhibits Na+-K+ ATPase by binding to K+ site

Flashcard 10: Ischemic priapism is treated with corporal aspiration, intracavernosal _____, or surgical decompression to prevent ischemia

Answer: phenylephrine

Extra:  https://onlinemeded.org?ref=anki