Influenza antivirals — Flashcards

Flashcard 1: Which anti-influenza drug increases dopamine synthesis/release and inhibits reuptake?_____

Answer: Amantadine

Flashcard 2: _____ inhibitors inhibit the enzyme responsible for cleaving proteins during viral replication

Answer: Protease

Flashcard 3: Which two anti-influenza drugs inhibit viral uncoating?_____

Answer: Amantadine and Rimantadine

Flashcard 4: Which two antiviral drugs directly inhibit DNA polymerase?_____

Answer: Foscarnet and Cidofovir

Flashcard 5: Which strain(s) of influenza are treated with M2 channel blockers (rimantidine, amantadine)?_____

Answer: Influenza A

Flashcard 6: Which type of HAART drug is Darunavir?_____

Answer: Protease inhibitor

Flashcard 7: What is the MOA of Cidofovir?_____

Answer: Preferential direct inhibition of viral DNA polymerase

Flashcard 8: amantadine

Answer:

Extra: Parkinson's disease, influenza A, rubellaexact mechanism unclear, but leads to increased dopamine releaseataxia

Flashcard 9: NRTIs and _____ both are reverse transcriptase inhibitors used in the treatment of HIV

Answer: NNRTIs

Extra:    https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 10: Enfuvirtide binds _____ of HIV inhibiting viral cell fusion with host cells

Answer: gp41

Extra:   Watch Maraviroc, fusion inhibitors, integrase inhibitors [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-antimicrobials/videos/medical-pharmacology-antimicrobials-antivirals-hiv-maraviroc-fusion-inhibitors-integrase-inhibitors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki