Combination antihypertensive therapy — Flashcards

Flashcard 1: When patients with Autosomal Dominant PKD develop hypertension or proteinuria, you may treat with _____

Answer: ACE inhibitors or ARBs (two types of drugs?)

Flashcard 2: -blockers may decrease BP by inhibiting 1 receptors of the JGA, thus decreasing _____ release

Answer: renin

Flashcard 3: Antihypertensives _____, a thiazide diuretic, is a first line agent for treating primary hypertension

Answer: Hydrochlorothiazide

Flashcard 4: What effect may ACE inhibitors have on potassium levels? _____

Answer: Increased (hyperkalemia)

Flashcard 5: Selective 1 adrenergic antagonists (except tamsulosin) may be used to treat _____ (BP)

Answer: hypertension

Flashcard 6: ACE inhibitors

Answer: renal damage

Flashcard 7: What is the mechanism of action of minoxidil? _____

Answer: Direct arteriolar vasodilator

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/cardiology/videos/hypertension?index=12] https://onlinemeded.org?ref=anki 

Flashcard 8: _____-dilators (e.g. hydralazine) cause decreased after-load

Answer: Vaso

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/cardiology/videos/pressure-volume-loops?index=4] https://onlinemeded.org/spa/cardiology/heart-failure/acquire?ref=anki 

Flashcard 9: _____ channel blockers are useful for treating hypertension

Answer: Ca2+

Extra:   Sketchy Pharmacology: Cardiovascular Watch Calcium channel blockers [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-cardiovascular-renal/videos/medical-pharmacology-cardiovascular-and-renal-antihypertensives-calcium-channel-blockers?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/cardiology/videos/vasodilation-and-vasoconstriction?index=8] https://onlinemeded.org/spa/cardiac?ref=anki 

Flashcard 10: ACE inhibitors and ARBs primarily cause _____ of the efferent arteriole of the kidney

Answer: dilation

Extra:  FA2020 UPDATE: ACE inhibitors dilate the efferent arteriole, not constrict as the image below states:  Sketchy Pharmacology: Cardiovascular/Renal Watch ACE inhibitors, ARBs, Aliskiren [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-cardiovascular-renal/videos/medical-pharmacology-cardiovascular-and-renal-heart-failure-drugs-ace-inhibitors-arbs-aliskiren?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/cardiology/hypertension/acquire?ref=anki