Antibiotics — Flashcards

Flashcard 591: Phase _____ of clinical trials detects rare or long-term adverse effects, and drug interactions

Answer: IV

Flashcard 592: Vancomycin is bacterio-_____

Answer: cidal

Flashcard 593: Which antibiotics bind the 23S rRNA of the 50S ribosomal subunit of bacteria?_____

Answer: Macrolides (-thromycin)

Flashcard 594: Cephalosporins: susceptibility to β-lactamases (penicillinases)

Answer: Relatively resistant (less susceptible than penicillins)

Extra: Cephalosporins are β-lactam antibiotics that are structurally more resistant to many β-lactamases (specifically penicillinases) compared to penicillins. However, they are still susceptible to specific enzymes like cephalosporinases and extended-spectrum β-lactamases (ESBLs).

Flashcard 595: Linezolid can result in _____-penia (hematologic complication)

Answer: thrombocyto

Flashcard 596: Resistance to Tetracyclines includes bacterial production of _____ pumps

Answer: efflux

Flashcard 597: What drug is an inhibitor of both prokaryotic AND eukaryotic RNA polymerase? _____

Answer: Actinomycin D

Flashcard 598: Which 3rd generation cephalosporin can treat Pseudomonas aeruginosa infection?_____

Answer: Ceftazidime

Flashcard 599: What cephalosporin can bind the altered PBPs of MRSA? _____

Answer: Ceftaroline

Flashcard 600: The metabolic acidosis associated with Isoniazid use has a(n) _____ anion gap (normal or elevated)

Answer: elevated