Skeletal muscle diseases — Flashcards

Flashcard 1: What vasculitis is a granulomatous, necrotizing vasculitis with eosinophilia?_____

Answer: Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis)

Flashcard 2: Non-enzymatic glycosylation of small vessels may cause nodular _____ with Kimmelstiel-Wilson nodules; may cause chronic renal failure

Answer: glomerulosclerosis

Flashcard 3: Which blistering skin disorder is characterized by fever and sloughing of skin at the dermal-epidermal junction? _____

Answer: Stevens-Johnson syndrome

Flashcard 4: X-linked muscular dystrophy is characterized by muscle wasting and replacement of skeletal muscle by _____ tissue

Answer: adipose

Flashcard 5: Niemann-Pick disease

Answer:

Extra: accumulation of sphingomyelinprogressive neurodegeneration, hepatosplenomegaly, cherry-red spot on macula foam cells Ashkenazi JewAR sphingomyelinase 

Flashcard 6: Gaucher's disease

Answer:

Extra: accumulation of glucocerebrosidehepatosplenomegaly, aseptic necrosis of femur, bone crisescrumpled-paper cells Ashkenazi JewARglucocerebrosidase

Flashcard 7: Patau's syndrome

Answer:

Extra: severe mental retardation, rocker-bottom feet, microopthalmia, microcephaly, cleft lip/palate, polydactyly, holoprosencephalyfirst trimester pregnancy screen: decreased - β-hCG, PAPP-A ultrasound: increased nuchal translucency in first trimesterdeath within first yeartrisomy 13

Flashcard 8: In metachromatic leukodystrophy, sulfatides accumulate in the lysosomes of _____

Answer: oligodendrocytes

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki Atlas: 

Flashcard 9: What type of cast may be seen in end-stage renal disease and chronic renal failure? _____

Answer: Waxy casts

Extra:   Watch Chronic Kidney Disease (CKD) [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-renal/videos/medical-pathophysiology-renal-congenital-and-chronic-kidney-disease-chronic-kidney-disease-ckd?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/nephrology/videos/pathology-diagnostics?index=6] https://onlinemeded.org/spa/nephrology/acute-kidney-injury/acquire?ref=anki Step Up to Medicine: Other: Goljan: 

Flashcard 10: _____ is characterized histologically by acanthosis with parakeratosis

Answer: Psoriasis

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/inflammatory-diseases-of-the-skin?index=10] https://onlinemeded.org/spa/musculoskeletal/inflammatory-dermatoses/acquire?ref=anki Atlas: