Systemic Pathology — Flashcards

Flashcard 971: Is Primary Myelofibrosis associated with JAK2 mutations?

Answer: Yes (approximately 50-60% of cases)

Flashcard 972: One hematological pathology that is due to abnormal splicing variants is _____

Answer: β-thalassemia

Extra: β-thalassemia is often caused by point mutations in promoter sequences or **splice sites** (leading to abnormal splicing variants). In contrast, α-thalassemia is primarily caused by gene deletions.

Flashcard 973: Which developmental pathology is characterized by bronchiectasis, recurrent sinusitis, and situs inversus? _____

Answer: Kartagener syndrome

Flashcard 974: _____ renal cysts are very common and account for majority of all renal masses; typically asymptomatic

Answer: Simple

Flashcard 975: DIC typically presents with _____ bleeding time

Answer: increased

Flashcard 976: One cause of anemia due to underproduction is parvovirus B19, which infects progenitor red cells and temporarily halts _____

Answer: erythropoiesis

Flashcard 977: Lichen _____ is hyperplasia of vulvar squamous epithelium

Answer: simplex chronicus

Flashcard 978: Histologically, patients with diabetic neuropathy will have endoneural arteriole _____

Answer: hyalinization

Flashcard 979: RPGN with a granular immunofluorescence pattern is more commonly due to _____

Answer: poststreptococcal glomerulonephritis

Flashcard 980: What is the prognosis of the mucinous carcinoma subtype of invasive ductal carcinoma (breast)? _____

Answer: Good