Systemic Pathology — Flashcards

Flashcard 881: Ammonium magnesium phosphate (struvite) kidney stones classically form _____ in renal calyces

Answer: staghorn calculi

Flashcard 882: The third most common type of kidney stone (5%) is a _____ stone

Answer: uric acid

Flashcard 883: Chronic Caisson disease (decompression sickness) is characterized by multifocal ischemic necrosis of _____

Answer: bone

Flashcard 884: What chromosomal deletion is associated with DiGeorge syndrome? _____

Answer: 22q11 microdeletion

Flashcard 885: Nephritic syndrome occurs due to _____ disruption

Answer: GBM

Flashcard 886: The 'tram-track' appearance associated with MPGN is due to basement membrane splitting caused by _____ cell ingrowth

Answer: mesangial

Flashcard 887: Frontotemporal dementia may have ubiquitinated _____ inclusions seen on histology

Answer: TDP-43

Extra: Frontotemporal Lobar Degeneration (FTLD) is divided into subtypes based on the protein inclusions: 1. **FTLD-TDP** (most common): TDP-43 inclusions; often associated with ALS (e.g., C9orf72 mutations). 2. **FTLD-Tau**: Tau inclusions; includes **Pick disease**, which is characterized by spherical Tau-positive Pick bodies. Note: While Pick bodies are ubiquitinated, TDP-43 is the protein specifically associated with the "ubiquitinated-only" (non-tau) inclusions in FTD.

Flashcard 888: Membranous nephropathy ultimately progresses to _____

Answer: chronic renal failure

Flashcard 889: What MSK pathology presents with bone pain and systemic signs of infection (e.g. fever, leukocytosis)?_____

Answer: Osteomyelitis

Flashcard 890: The E. coli O157:H7 _____-toxin damages endothelial cells, resulting in platelet microthrombi (e.g. HUS)

Answer: vero