Liver pathology (hepatitis, cirrhosis) — Flashcards

Flashcard 1: Wilson disease is also known as _____

Answer: hepatolenticular degeneration

Flashcard 2: What pathologic RBC is seen in liver disease and abetalipoproteinemia (states of cholesterol dysregulation)?_____

Answer: Acanthocytes

Flashcard 3: Patients with sarcoidosis may have scattered granulomas in their liver; most commonly affecting the _____

Answer: portal triads

Flashcard 4: Poliovirus causes a(n) _____ paralysis (symmetric/asymmetric)

Answer: asymmetric

Flashcard 5: Herpes encephalitis is associated with _____ protein in the CSF

Answer: increased

Flashcard 6: What pathology is characterized by a defective type IV collagen? _____

Answer: Alport syndrome

Flashcard 7: Niemann-Pick disease

Answer:

Extra: accumulation of sphingomyelinprogressive neurodegeneration, hepatosplenomegaly, cherry-red spot on macula foam cells Ashkenazi JewAR sphingomyelinase 

Flashcard 8: Gaucher's disease

Answer:

Extra: accumulation of glucocerebrosidehepatosplenomegaly, aseptic necrosis of femur, bone crisescrumpled-paper cells Ashkenazi JewARglucocerebrosidase

Flashcard 9: Patau's syndrome

Answer:

Extra: severe mental retardation, rocker-bottom feet, microopthalmia, microcephaly, cleft lip/palate, polydactyly, holoprosencephalyfirst trimester pregnancy screen: decreased - β-hCG, PAPP-A ultrasound: increased nuchal translucency in first trimesterdeath within first yeartrisomy 13

Flashcard 10: In metachromatic leukodystrophy, sulfatides accumulate in the lysosomes of _____

Answer: oligodendrocytes

Extra:   https://onlinemeded.org/spa/metabolism?ref=anki Atlas: