Neoplasia — Flashcards

Neoplasia US Medical PG Flashcards - Medical Study Cards

Master Neoplasia with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.

Neoplasia Flashcard Deck - 10 Cards

Flashcard 261: The t(15;17) translocation seen in acute promyelocytic leukemia results in disruption of the _____ receptor on chromosome 17

Answer: retinoic acid

Extra: Watch Acute Myeloid Leukemia (AML) & Chronic Myeloid Leukemia (CML) [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-myeloid-lymphoid/videos/medical-pathophysiology-myeloid-and-lymphoid-myeloid-disorders-acute-myeloid-leukemia-aml-and-chronic-myeloid-leukemia-cml?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/hematology-and-oncology/videos/leukemias-and-lymphomas?index=2] https://onlinemeded.org/spa/hematology-oncology/leukemia/acquire?ref=anki Other:

Flashcard 262: Metastasis of medulloblastomas to the _____ is termed "drop metastasis"

Answer: spinal cord

Extra: * Medulloblastoma in 4th ventricle may send "drop metastasis" (cells "fall down" central canal in CSF) to spinal cord Watch Pediatric CNS Tumors [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-neuro/videos/medical-pathophysiology-neuro-intracranial-hypertension-and-tumors-pediatric-cns-tumors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/pediatric-brain-tumors?index=4] https://onlinemeded.org?ref=anki Medulloblastoma T2-weighted cranial MRI (axial view) of a 7-year-old boy: isodense round lesion with hyperintense sections in the fourth ventricle (green overlay); grossly diminished gyration of the cerebellum (C). (P = poorly demarcated pons region; B = basilar artery, CS = external CSF space) Medulloblastoma T1-weighed cranial MRI of a 6-year-old child presenting with features of increased intracranial pressure (midsagittal section with contrast) There is a large hypointense mass occupying the third (upper yellow overlay) and fourth (lower yellow overlay) ventricles that is causing obstructive hydrocephalus (pink overlay). The pink overlay also highlights the leakage of CSF into the periventricular space (transependymal edema) and into the occipital lobe due to the increased intraventricular pressure. This appearance of a fourth ventricular mass in a child is characteristic of medulloblastoma. Medulloblastoma Cranial MRI (T1-weighted, with contrast) There is a mass in the posterior cranial fossa. It features solid parts (green overlay) and cystic parts (red overlay). Location and appearance are typical of a medulloblastoma. (D: diencephalon; P: pons; C: cerebellum; yellow outline: cerebellar tentorium) Medulloblastoma Photomicrograph of cerebellar vermis tissue (H&E stain) Densely packed, small, blue anaplastic cells are present throughout the specimen. The cells have pleomorphic and hyperchromatic nuclei. On the right, a vessel (its lumen mostly obstructed by eosinophilic material) can be seen. These are typical histopathological findings of medulloblastoma. Medulloblastoma Photomicrograph of cerebellar vermis tissue (H&E stain) Numerous small, blue, round cells with scant cytoplasm can be seen throughout the specimen (classic examples: arrows, green overlay). Their nuclei vary in size and structure (nuclear pleomorphism) and many cells feature distinctly hyperchromatic nuclei. The majority of the cells are arranged in concentric clusters around lighter central areas consisting of neuropil (examples: dashed outlines and yellow overlay, magnified area). These clusters are referred to as Homer Wright rosettes. These histopathological features, particularly the Homer Wright rosettes, are characteristic of a medulloblastoma. Atlas:

Flashcard 263: The immunoglobulin heavy chain (IgH) sits on chromosome _____

Answer: 14

Extra: https://onlinemeded.org/spa/immunology?ref=anki

Flashcard 264: Is medulloblastoma typically seen in adults or children? _____

Answer: Children

Extra: Watch Pediatric CNS Tumors [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-neuro/videos/medical-pathophysiology-neuro-intracranial-hypertension-and-tumors-pediatric-cns-tumors?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/pediatric-brain-tumors?index=4] https://onlinemeded.org?ref=anki Medulloblastoma T2-weighted cranial MRI (axial view) of a 7-year-old boy: isodense round lesion with hyperintense sections in the fourth ventricle (green overlay); grossly diminished gyration of the cerebellum (C). (P = poorly demarcated pons region; B = basilar artery, CS = external CSF space) Medulloblastoma T1-weighed cranial MRI of a 6-year-old child presenting with features of increased intracranial pressure (midsagittal section with contrast) There is a large hypointense mass occupying the third (upper yellow overlay) and fourth (lower yellow overlay) ventricles that is causing obstructive hydrocephalus (pink overlay). The pink overlay also highlights the leakage of CSF into the periventricular space (transependymal edema) and into the occipital lobe due to the increased intraventricular pressure. This appearance of a fourth ventricular mass in a child is characteristic of medulloblastoma. Medulloblastoma Cranial MRI (T1-weighted, with contrast) There is a mass in the posterior cranial fossa. It features solid parts (green overlay) and cystic parts (red overlay). Location and appearance are typical of a medulloblastoma. (D: diencephalon; P: pons; C: cerebellum; yellow outline: cerebellar tentorium) Medulloblastoma Photomicrograph of cerebellar vermis tissue (H&E stain) Densely packed, small, blue anaplastic cells are present throughout the specimen. The cells have pleomorphic and hyperchromatic nuclei. On the right, a vessel (its lumen mostly obstructed by eosinophilic material) can be seen. These are typical histopathological findings of medulloblastoma. Medulloblastoma Photomicrograph of cerebellar vermis tissue (H&E stain) Numerous small, blue, round cells with scant cytoplasm can be seen throughout the specimen (classic examples: arrows, green overlay). Their nuclei vary in size and structure (nuclear pleomorphism) and many cells feature distinctly hyperchromatic nuclei. The majority of the cells are arranged in concentric clusters around lighter central areas consisting of neuropil (examples: dashed outlines and yellow overlay, magnified area). These clusters are referred to as Homer Wright rosettes. These histopathological features, particularly the Homer Wright rosettes, are characteristic of a medulloblastoma. Atlas:

Flashcard 265: Striated muscle can give rise to a(n) _____ (benign) and rhabdomyosarcoma (malignant)

Answer: rhabdomyoma

Extra: https://onlinemeded.org?ref=anki

Flashcard 266: Lobular carcinoma in situ (LCIS) is often discovered _____; does not produce mass or calcification

Answer: incidentally

Extra: Watch Breast Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-breast-breast-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/surgery-general/breast-cancer/acquire?ref=anki

Flashcard 267: What nonkeratinized squamous cell malignancy of the anus arises near the dentate/pectinate line? _____

Answer: Basaloid carcinoma

Extra: Watch Anorectal Disorders [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-gi/videos/medical-pathophysiology-gi-colorectal-and-anal-disorders-anorectal-disorders?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/dermatology/videos/malignant-skin-disorders?index=2] https://onlinemeded.org?ref=anki

Flashcard 268: Testicular germ cell tumors that are _ (43%) have variable responses to radiotherapy and metastasize _

Answer: non-seminomas

Extra: * e.g. teratomas & yolk sac (endodermal sinus) tumors Watch Testicular Disorders & Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-male-gu-testicular-disorders-and-cancer?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki

Flashcard 269: _____ is a malignant germ cell tumor composed of mononuclear cytotrophoblasts and multinuclear syncytiotrophoblasts, but with absent villi

Answer: Choriocarcinoma

Extra: Watch Hydatidiform Mole & Choriocarcinoma [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-gestational-disorders-hydatidiform-mole-and-choriocarcinoma?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch Testicular Disorders & Cancer [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-reproductive-gu/videos/medical-pathophysiology-reproductive-and-gu-gestational-disorders-hydatidiform-mole-and-choriocarcinoma?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org?ref=anki

Flashcard 270: Which type of stomach carcinoma are nitrosamines related to? _____

Answer: Intestinal type of Stomach Carcinoma

Extra: https://onlinemeded.org?ref=anki

Keywords: Neoplasia flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards

Study by Chapter

Characteristics of benign vs malignant tumors

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Nomenclature of neoplasms

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Carcinogenesis models

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Oncogenes and proto-oncogenes

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Tumor suppressor genes

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DNA repair genes and cancer

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Epigenetic mechanisms in cancer

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Apoptosis and cancer

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Tumor angiogenesis

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Tumor invasion and metastasis

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Carcinogenic agents

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Paraneoplastic syndromes

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Tumor immunology

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