Neoplasia — Flashcards

Flashcard 1361: Pancreatic adenocarcinoma is a very aggressive tumor arising from the pancreatic _____ (ducts or acini)

Answer: ducts

Flashcard 1362: Invasive carcinoma cells first bind to basement membrane via _____

Answer: Laminin receptors

Extra: Steps of tumor invasion and metastasis: 1. Loosening of cell-cell junctions (e.g., loss of E-cadherin) 2. Attachment to basement membrane (via laminin receptors) 3. Degradation of ECM (via proteases like metalloproteinases and cathepsin D) 4. Migration (via autocrine motility factors)

Flashcard 1363: Which form of radiation is associated with the following types of cancer?_____ Basal Cell Carcinoma of the SkinSquamous Cell Carcinoma of the SkinMelanoma of the Skin

Answer: Non-Ionizing Radiation

Flashcard 1364: Dysplasia is a term used only with _____ cells

Answer: epithelial

Flashcard 1365: Which part of the urinary tract does adenocarcinoma most commonly occur?

Answer: Bladder

Extra: Adenocarcinoma of the bladder is rare (the most common bladder cancer is urothelial/transitional cell carcinoma). Primary adenocarcinoma of the urinary tract (excluding renal cell carcinoma) is most common in the **bladder**, specifically associated with: 1. **Urachal remnants** (typically involves the **dome** of the bladder) 2. **Bladder exstrophy** (the most common malignancy in these patients) 3. **Cystitis glandularis** (intestinal metaplasia resulting from chronic irritation) *Note: While Renal Cell Carcinoma is an adenocarcinoma of the kidney, the "urinary tract" in pathology often refers to the urothelium-lined collecting system (ureters, bladder, urethra).*

Flashcard 1366: Do hamartomatous colonic polyps have significant risk of malignant transformation? _____

Answer: No

Flashcard 1367: Eosinophilic granuloma is a _____ proliferation (benign or malignant) of Langerhans cells

Answer: benign

Flashcard 1368: _____ (leukemias or lymphomas) are neoplastic proliferations of lymphoid cells that form a mass

Answer: Lymphomas

Flashcard 1369: _____ is a benign small, well-defined mobile breast mass composed of fibrous tissue and glands

Answer: Fibroadenoma

Flashcard 1370: Are craniopharyngiomas benign or malignant?_____

Answer: Benign