DNA repair genes and cancer — Flashcards

Flashcard 1: What pathology is characterized by a deficiency of the enzymes used in mismatch base repair? _____

Answer: Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC])

Flashcard 2: Lynch syndrome and some sporadic colorectal carcinomas arise via the _____ instability pathway

Answer: microsatellite

Flashcard 3: Homologous Recombination is defective in breast/ovarian cancers with _____ mutations

Answer: BRCA1/2

Flashcard 4: Which tumor suppressor genes are associated with breast, ovarian, fallopian and pancreatic cancer?_____

Answer: BRCA1/BRCA2

Flashcard 5: Which autosomal dominant syndrome is associated with increased risk for colon, ovarian, and endometrial carcinoma? _____

Answer: Lynch syndrome (HNPCC)

Flashcard 6: What type of gene is the APC gene? _____

Answer: Tumor suppressor gene

Flashcard 7: fibroma

Answer:

Extra: pulling sensation in groinbundles of spindle-shaped fiibroblasts

Flashcard 8: Brenner tumor

Answer:

Extra: "coffee bean" nuclei on H&E Solid tumor, tan-yellow color, appears encapsulated. Looks like bladderbenign

Flashcard 9: mucinous cystadenocarcinoma

Answer:

Extra: malignant

Flashcard 10: mucinous cystadenoma

Answer:

Extra: multilocular cyst with mucous secreting epitheliumbenign