NRTI, NNRTI, PI, INSTI, and entry inhibitors — Flashcards

Flashcard 1: HIV initially infects what cell type?_____

Answer: Macrophages

Flashcard 2: Which gene is mutated in HIV protease inhibitor resistance?_____

Answer: pol gene

Flashcard 3: Which enzyme allows for HIV dsDNA to integrate with host cell DNA?_____

Answer: Integrase

Flashcard 4: Which viral gene in HIV codes for its Aspartate Protease?_____

Answer: pol

Flashcard 5: What infectious disease is an irreversible cause of dementia? _____

Answer: HIV

Flashcard 6: Which viral gene in HIV codes for its Integrase?_____

Answer: pol

Flashcard 7: progressive multifocal leukoencephalopathy (PML)

Answer:

Extra: destruction of oligodendrocytes, demyelination of CNSrapidly progressive, usually fatalrecent JC virus infection, AIDS

Flashcard 8: The _____ blot *used to be* the confirmatory test for HIV after a positive ELISA

Answer: Western

Extra:   https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 9: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)? _____

Answer: gp120

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki 

Flashcard 10: Which HIV gene encodes for the virion p24 (Capsid) and p17 (Matrix) core proteins? _____

Answer: gag

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki