Acute HIV infection — Flashcards

Flashcard 1: Reactivation of CMV from mononuclear cells occurs via _____

Answer: immunosuppression (organ transplant, AIDS patients)

Flashcard 2: Which two regulatory proteins of HIV are required for viral replication?_____

Answer: Rev and Tat

Flashcard 3: HIV later on infects what cell type?_____

Answer: CD4+ Helper T cells

Flashcard 4: Which envelope protein on HIV binds the CD4 molecule and a chemokine receptor (CXCR4 or CCR5)?_____

Answer: gp120

Flashcard 5: Which viral gene in HIV codes for the p17 matrix protein?_____

Answer: gag

Flashcard 6: _____ are diploid single-stranded RNA viruses

Answer: Retroviruses (ie: HIV)

Flashcard 7: _____ is the transmembrane protein of HIV, mediating viral-cell fusion and syncytia formation

Answer: gp41

Flashcard 8: progressive multifocal leukoencephalopathy (PML)

Answer:

Extra: destruction of oligodendrocytes, demyelination of CNSrapidly progressive, usually fatalrecent JC virus infection, AIDS

Flashcard 9: The _____ blot *used to be* the confirmatory test for HIV after a positive ELISA

Answer: Western

Extra:   https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 10: Which HIV gene encodes for the virion p24 (Capsid) and p17 (Matrix) core proteins? _____

Answer: gag

Extra:    https://onlinemeded.org/spa/microbiology/antivirals/acquire?ref=anki