Transcription/translation — Flashcards

Flashcard 171: The _____ of tRNA contains the TΨC sequence (ribothymidine, pseudouridine, cytidine) necessary for tRNA-ribosome binding

Answer: T-arm

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-replication-transcription-and-translation?index=8] https://onlinemeded.org?ref=anki 

Flashcard 172: _____ is a specific transcription factor that binds kB elements, which regulates expression of many genes in the immune system

Answer: Nuclear factor kappa B (NF-kB)

Extra:   https://onlinemeded.org/spa/endocrinology/adrenals/acquire?ref=anki 

Flashcard 173: _____ proteins are specific transcription factors that regulate gene expression during development

Answer: Homeodomain

Flashcard 174: In the final step of translation elongation, _____ of the ribosome occurs, advancing the ribosome 3 nucleotides towards the 3' end of mRNA

Answer: translocation

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-replication-transcription-and-translation?index=8] https://onlinemeded.org?ref=anki 

Flashcard 175: In the ER, co-translational _____ adds sugars onto the amino acid asparagine

Answer: N-glycosylation

Extra:   Watch Amino Acids (Overview) [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-amino-acids-and-proteins-amino-acids-overview?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/dna-to-protein/amino-acids/acquire?ref=anki 

Flashcard 176: The two ribosomal subunits in eukaryotes are _____S and _____S making _____S

Answer: 60

Extra:  https://onlinemeded.org/spa/infectious-disease?ref=anki 

Flashcard 177: Once bound (activated), the glucocorticoid receptor enters the nucleus and binds to _____ to regulate gene transcription

Answer: glucocorticoid response elements

Extra:   Sketchy Pharmacology: Thyroid, Pituitary, & Adrenal Watch Glucocorticoids [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-gi-endocrine/videos/medical-pharmacology-gi-and-endocrine-thyroid-parathyroid-and-adrenal-glucocorticoids?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] https://onlinemeded.org/spa/endocrinology/adrenals/acquire?ref=anki 

Flashcard 178: ACTH is a(n) _____ hormone

Answer: polypeptide

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 179: _____ will result in: HbA = 0% HbS = 0% HbF ≈ 97.5% HbA2 ≈ 2.5%

Answer: β-thalassemia major (β0/β0)

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 180: 32 y/o man is recovering from extensive burns. -Fibroblasts near site of injury actively synthesize precursor mRNA. -The finalized mRNA then exits the nucleus and undergoes translation. -Which steps involving processing and handling of mRNA occur only within the cytoplasm of cells?

Answer: Interaction with P bodies. They play an important role in mRNA translation, regulation and mRNA degradation. They are located in cytoplasm.