WNT signaling pathway — Flashcards

Flashcard 1: What is the mechanism that results in malignancy from the RAS oncogene?_____

Answer: point mutation

Flashcard 2: What type of oncogene is RAS?_____

Answer: GTP-binding protein (signal transducer)

Flashcard 3: Tumor suppressor genes _____ cell growth

Answer: regulate

Flashcard 4: MUTYH-associated polyposis is an _____ syndrome with multiple colorectal adenomas and an increased risk of colorectal cancer.

Answer: autosomal recessive (inheritance)

Flashcard 5: Which tumor suppressor genes are associated with colon cancer?_____

Answer: DCC, APC

Flashcard 6: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 7: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 8: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 9: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate

Flashcard 10: How does a direct enzyme-linked immunosorbent assay (ELISA) work?

Answer: 1. Patient's blood sample washed over a fixed antibody linked to a color-generating enzyme. 2. Any antibody-antibody-enzyme complex produces color change.