Tyrosine kinase receptors — Flashcards

Flashcard 1: One type of receptor tyrosine kinase is a _____, which dimerizes and auto-phosphorylates upon binding of a hormone or ligand

Answer: monomer

Flashcard 2: Insulin increases expression of the GLUT4 transporter on adipose and muscle tissue via the _____ signaling pathway

Answer: PI3 kinase

Flashcard 3: What type of oncogene is RAS?_____

Answer: GTP-binding protein (signal transducer)

Flashcard 4: When insulin binds to its receptor, _____ is activated and autophosphorylates the -subunits

Answer: tyrosine kinase

Flashcard 5: Which type of receptor is associated with growth hormone?_____

Answer: Receptor associated tyrosine kinase

Flashcard 6: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 7: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 8: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 9: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate

Flashcard 10: How does a direct enzyme-linked immunosorbent assay (ELISA) work?

Answer: 1. Patient's blood sample washed over a fixed antibody linked to a color-generating enzyme. 2. Any antibody-antibody-enzyme complex produces color change.