TGF-β/SMAD signaling — Flashcards

Flashcard 1: What type of receptor do growth hormones use for their signaling pathways? _____

Answer: Receptor associated tyrosine kinases

Flashcard 2: Which tumor suppressor genes are associated with colon cancer?_____

Answer: DCC, APC

Flashcard 3: What is the primary role of fibroblast growth factor (FGF-2)? _____

Answer: Angiogenesis

Flashcard 4: The APC tumor suppresor regulates the Wnt signalling pathway by destroying _____ in the absence of a Wnt receptor-ligand interaction

Answer: B-catenin

Flashcard 5: What type of oncogene is ABL?_____

Answer: Tyrosine kinase (signal transducer)

Flashcard 6: What protein in hemidesmosomes binds to fibronectin, laminin, or collagen in the basement membrane? _____ *bonus-Ca2+ dependent? Y/N

Answer: Integrin

Flashcard 7: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 8: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 9: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 10: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate