Second messenger systems (cAMP, cGMP, Ca2+) — Flashcards

Flashcard 1: _____ proteins are specific transcription factors that bind to cAMP response elements (CREs) to cause a response to cAMP

Answer: cAMP response element binding (CREB)

Flashcard 2: Pertussis toxin ribosylates Gi, _____ the G-protein receptor (activating or inhibiting)

Answer: inhibiting

Flashcard 3: What hormone acts through a receptor guanylyl cyclase? _____

Answer: Atrial natriuretic peptide (ANP)

Flashcard 4: What type of receptor do growth hormones use for their signaling pathways? _____

Answer: Receptor associated tyrosine kinases

Flashcard 5: After the subunit is bound by GTP (cellular signaling), the -GTP subunit _____ from its respective G protein (i.e. Gs, Gi, or Gq)

Answer: detaches

Flashcard 6: TRH acts on which signalling cascade? _____

Answer: IP3

Flashcard 7: NADPH oxidase

Answer: respiratory burst

Extra: O2O2-

Flashcard 8: Give the pathway by which glucagon/Epi regulate glycogen.

Answer: glucagon/Epi, adenylyl cyclase, cAMP, protein kinase A, glycogen phosphorylsae kinase, glycogen phosphorylase

Flashcard 9: Give the pathway by which insulin regulates glycogen.

Answer: insulin, tyrosine kinase receptor, protein phosphatases, inactivated glycogen phosphorylase kinase and glycogen phorphorylase

Flashcard 10: If an enyzme is a kinase, what do you know about its function?

Answer: uses ATP to add phosphate group to substrate